49 Results for "

tumor-specific

" in MedChemExpress (MCE) Product Catalog:
Products (49)

49 Results for "tumor-specific" in MCE Product Catalog:

30
Mertansine
Mertansine
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30 Publications Verification
Cat. No.: HY-19792
CAS No.: 139504-50-0
Synonyms: DM1; Maytansinoid DM1
Target:  

Microtubule/Tubulin ADC Payloads

Research Areas:  

Cancer

Mertansine (DM1) is a microtubulin inhibitor and is an antibody-conjugatable maytansinoid that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug conjugate (ADC) .
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6
BJE6-106
BJE6-106
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6 Cited Publications
Cat. No.: HY-117800
CAS No.: 1564249-38-2
Purity:  99.85%
Synonyms: B106
Target:  

PKC Apoptosis

Research Areas:  

Inflammation/Immunology Cancer

BJE6-106 (B106) is a potent, selective 3 rd generation PKCδ inhibitor with an IC50 of 0.05 μM and targets selectivity over classical PKC isozyme PKCα (IC50=50 μM). BJE6-106 (B106) induces caspase-dependent apoptosis. BJE6-106 (B106) possesses tumor-specific effect.
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1
Gatipotuzumab
Gatipotuzumab
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1 Cited Publications
Cat. No.: HY-P99634
CAS No.: 1264737-26-9
Synonyms: PankoMab; DS-3939a antibody

Target:  

Mucin

Research Areas:  

Cancer

Gatipotuzumab (PankoMab) is a humanized monoclonal antibody which recognizes the tumor-specific epitope of mucin-1 (TA-MUC1). Gatipotuzumab reveals a potent tumor-specific antibody-dependent cell cytotoxicity (ADCC) .
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1
Cadonilimab
Cadonilimab
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1 Cited Publications
Cat. No.: HY-P99117
CAS No.: 2394841-59-7
Synonyms: AK104

Target:  

PD-1/PD-L1 CTLA-4

Research Areas:  

Inflammation/Immunology Cancer

Cadonilimab (AK104) is a humanized tetravalent IgG1 bispecific antibody targeting PD1/CTLA4. Cadonilimab blocks both PD-1 and CTLA-4 pathways, thereby relieving their corresponding immunosuppressive effects and reversing tumor specific T cell exhaustion. Cadonilimab significantly downregulates Fc-mediated effector functions, including antibody-dependent cell-mediated cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), complement dependent cytotoxicity (CDC). Cadonilimab can be used for research of metastatic cervical cancer, as well as other malignancies such as gastric cancer, GEJ adenocarcinoma and non-small cell lung cancer (NSCLC) .
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1
Mitazalimab
Mitazalimab
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1 Cited Publications
Cat. No.: HY-P99742
CAS No.: 2055640-86-1
Synonyms: ADC-1013; JNJ-64457107; Vanalimab

Target:  

TNF Receptor

Research Areas:  

Cancer

Mitazalimab (ADC-1013; JNJ-64457107) is FcγR-dependent CD40 agonist with tumor-directed activity. Mitazalimab activates antigen-presenting cells, e.g. dendritic cells (DC), to initiate tumor-reactive T cells. Therefore, Mitazalimab induces tumor-specific T cells to infiltrate and kill tumors. Mitazalimab remodels the tumor-infiltrating myeloid microenvironment .
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1
Neoliquiritin
Neoliquiritin
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1 Cited Publications
Cat. No.: HY-N2123
CAS No.: 5088-75-5
Category:  

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