10787 Results for "

ucleotide small endogenous non-coding RNA

" in MedChemExpress (MCE) Product Catalog:
Products (10787)

10787 Results for "ucleotide small endogenous non-coding RNA" in MCE Product Catalog:

307
Gemcitabine
Gemcitabine
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307 Publications Verification
Cat. No.: HY-17026
CAS No.: 95058-81-4
Synonyms: LY 188011
Target:  

Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Autophagy Apoptosis p38 MAPK

Research Areas:  

Infection Inflammation/Immunology Cancer

Gemcitabine (LY 188011) is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine inhibits DNA synthesis and repair, and can modulate autophagy. Gemcitabine induces apoptosis through the activation of p38 MAPK. Gemcitabine demonstrates efficacy in mouse models of pancreatic and breast cancer. Gemcitabine can be used for cancer research, such as pancreatic cancer, non-small cell lung cancer, and breast cancer .
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230
Remdesivir
Remdesivir
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230 Cited Publications
Cat. No.: HY-104077
CAS No.: 1809249-37-3
Purity:  99.95%
Synonyms: GS-5734
Target:  

DNA/RNA Synthesis SARS-CoV

Research Areas:  

Infection

Remdesivir (GS-5734) is a nucleoside analogue with effective antiviral activity. Remdesivir can inhibit the synthesis of viral DNA or RNA. Remdesivir can be used for the research of infection, such as SARS-CoV and MHV infection .
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206
Dihydroethidium
Dihydroethidium
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206 Cited Publications
Cat. No.: HY-D0079
CAS No.: 104821-25-2
Synonyms: Hydroethidine; PD-MY 003
Dihydroethidium, also known as DHE, is a peroxide indicator. Dihydroethidium penetrates cell membranes to form a fluorescent protein complex with blue fluoresces. After entering the cells, Dihydroethidium is mainly localized in the cell membrane, cytoplasm and nucleus, and the staining effect is the strongest in the nucleus. Dihydroethidium produces inherent blue fluorescence with a maximum excitation wavelength of 370 nm and a maximum emission wavelength of 420 nm; after dehydrogenation, Dihydroethidium combines with RNA or DNA to produce red fluorescence with a maximum excitation wavelength of 300 nm and a maximum emission wavelength of 610 nm. 535 nm can also be used as the excitation wavelength for actual observation .
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179
ATP disodium salt
ATP disodium salt
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179 Cited Publications
Cat. No.: HY-B0345A
CAS No.: 987-65-5
Synonyms: Adenosine 5'-triphosphate disodium salt; Disodium adenosine triphosphate
Category:  

Natural Products Microorganisms Animals Plants Other Families Extract Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:  

Endogenous Metabolite

ATP disodium salt (Adenosine 5'-triphosphate disodium salt) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt is an important endogenous signaling molecule in immunity and inflammation .
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159
Protease and Phosphatase Inhibitor Cocktail (EDTA-Free, 10× in ddH2O)
Protease and Phosphatase Inhibitor Cocktail (EDTA-Free, 10× in ddH2O)
0 Images
159 Cited Publications
Cat. No.: HY-K0013

MCE Protease and Phosphatase Inhibitor Cocktail (EDTA-Free, 10× in ddH2O) protects protein from degradation by endogenous proteases released during protein extraction and purification.The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

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130
Sotorasib
Sotorasib
0 Images
130 Cited Publications
Cat. No.: HY-114277
CAS No.: 2296729-00-3
Purity:  99.94%
Synonyms: AMG-510
Target:  

Ras

Research Areas:  

Cancer

Sotorasib (AMG-510) is a first-in-class, orally bioavailable, and selective KRAS G12C covalent inhibitor. Sotorasib irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state. Sotorasib leads to the regression of KRAS G12C‑mutated locally advanced or metastatic non‑small cell lung cancer (NSCLC) .
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122
Telaglenastat
Telaglenastat
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122 Cited Publications
Cat. No.: HY-12248
CAS No.: 1439399-58-2
Purity:  99.82%
Synonyms: CB-839
Target:  

Glutaminase Autophagy

Research Areas:  

Cancer

Telaglenastat (CB-839) is a first-in-class, selective, reversible and orally active glutaminase 1 (GLS1) inhibitor. Telaglenastat selectively inhibits GLS1 splice variants KGA (kidney-type glutaminase) and GAC (glutaminase C) compared to GLS2. The IC50s are 23 nM and 28 nM for endogenous glutaminase in mouse kidney and brain, respectively. Telaglenastat inuduces autophagy and has antitumor activity .
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122
Telaglenastat hydrochloride
Telaglenastat hydrochloride
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122 Cited Publications
Cat. No.: HY-12248A
CAS No.: 1874231-60-3
Synonyms: CB-839 hydrochloride
Target:  

Glutaminase Autophagy

Research Areas:  

Cancer

Telaglenastat (CB-839) hydrochloride is a first-in-class, selective, reversible and orally active glutaminase 1 (GLS1) inhibitor. Telaglenastat hydrochloride selectively inhibits GLS1 splice variants KGA (kidney-type glutaminase) and GAC (glutaminase C) compared to GLS2. The IC50s are 23 nM and 28 nM for endogenous glutaminase in mouse kidney and brain, respectively. Telaglenastat hydrochloride inudces autophagy and has antitumor activity .
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120
Sofosbuvir
Sofosbuvir
0 Images
120 Cited Publications
Cat. No.: HY-15005
CAS No.: 1190307-88-0
Purity:  99.97%
Synonyms: GS-7977; PSI-7977
Target:  

HCV

Research Areas:  

Infection Cancer

Sofosbuvir (GS-7977) is an HCV RNA replication inhibitor with an EC50 of 92 nM .
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117
Afatinib
Afatinib
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117 Cited Publications
Cat. No.: HY-10261
CAS No.: 850140-72-6
Purity:  99.92%
Synonyms: BIBW 2992
Target:  

EGFR Autophagy Apoptosis c-Met/HGFR Akt p38 MAPK

Research Areas:  

Cancer

Afatinib (BIBW 2992) is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFR wt, EGFR L858R, EGFR L858R/T790M and HER2, respectively. Afatinib can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer .
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117
Afatinib dimaleate
Afatinib dimaleate
0 Images
117 Cited Publications
Cat. No.: HY-10261A
CAS No.: 850140-73-7
Purity:  99.74%
Synonyms: BIBW 2992MA2
Target:  

EGFR Autophagy Apoptosis c-Met/HGFR Akt p38 MAPK

Research Areas:  

Cancer

Afatinib (BIBW 2992) dimaleate is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFR wt, EGFR L858R, EGFR L858R/T790M and HER2, respectively. Afatinib dimaleate can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer .
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99
Luteolin monohydrate
Luteolin monohydrate
0 Images
99 Cited Publications
Cat. No.: HY-W303895
CAS No.: 6113-16-2
Target:  

Keap1-Nrf2 Apoptosis Autophagy Endogenous Metabolite

Research Areas:  

Others Cancer

Luteolin (monohydrate) is the monohydrate of Luteolin. Luteolin (Luteoline), a flavonoid, is also a potent Nrf2 inhibitor. Luteolin has anti-inflammatory and anticancer properties, induces apoptosis and cell cycle arrest in multiple human cancer cell lines, including non-small lung cancer cells, and inhibits cell metastasis and angiogenesis .
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99
Luteolin
Luteolin
0 Images
99 Cited Publications
Cat. No.: HY-N0162
CAS No.: 491-70-3
Synonyms: Luteoline; Luteolol; Digitoflavone
Category:  

Flavones Plants Other Families Extract Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Microorganisms Phenols Polyphenols Disease Research Fields Inflammation/Immunology

Target:  

Keap1-Nrf2 Apoptosis Autophagy Endogenous Metabolite

Luteolin (Luteoline), a flavanoid compound, is a potent Nrf2 inhibitor. Luteolin has anti-inflammatory, anti-cancer properties, including the induction of apoptosis and cell cycle arrest, and the inhibition of metastasis and angiogenesis, in several cancer cell lines, including human non-small lung cancer cells .
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93
Calcein-AM
Calcein-AM
0 Images
93 Cited Publications
Cat. No.: HY-D0041
CAS No.: 148504-34-1
Synonyms: Calcein acetoxymethyl ester
Calcein AM, has cell membrane permeability and can easily enter the cell. Calcein AM has no fluorescence and is hydrolyzed by endogenous esterase in the cell to produce polar molecule Calcein (Calcein), which has strong negative charge and cannot permeate the cell membrane. Calcein can emit strong green fluorescence, so it is often used with Propidium Iodide for cell viability/virulence detection, excitation/emission wavelength: 494/515 nm .
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92
L-Ascorbic acid sodium salt
L-Ascorbic acid sodium salt
0 Images
92 Cited Publications
Cat. No.: HY-B0166A
CAS No.: 134-03-2
Synonyms: Sodium ascorbate; Sodium L-ascorbate; Vitamin C sodium salt
Category:  

Natural Products Plants Other Families Extract Disease Research Fields Cancer

Target:  

Environmental Pollutants Apoptosis Endogenous Metabolite Calcium Channel Reactive Oxygen Species (ROS)

L-Ascorbic acid sodium salt (Sodium ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid sodium salt selectively inhibits Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid sodium salt is also a collagen deposition enhancer and an elastogenesis inhibitor .
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92
L-Ascorbic acid
L-Ascorbic acid
0 Images
92 Cited Publications
Cat. No.: HY-B0166
CAS No.: 50-81-7
Synonyms: L-Ascorbate; Vitamin C
Category:  

Natural Products Moringaceae Extract Neurological Disease 500 - Internal Server Error | MedChemExpress

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