86

Sulfasalazine

86 Publications Verification

Cat. No.: HY-14655

CAS No.: 599-79-1

Purity: 98.75%

Synonyms: NSC 667219; Salicylazosulfapyridine

Target:

NF-κB Autophagy Apoptosis Ferroptosis Bacterial Antibiotic

Research Areas:

Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer .

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14

Dexamethasone phosphate

14 Cited Publications

Cat. No.: HY-B1829

CAS No.: 312-93-6

Synonyms: Dexamethasone 21-phosphate

Target:

Glucocorticoid Receptor TGF-β Receptor Interleukin Related

Research Areas:

Neurological Disease Inflammation/Immunology

Dexamethasone phosphate (Dexamethasone 21-phosphate) is a prodrug form of the glucocorticoid Dexamethasone (HY-14648). Dexamethasone phosphate is prepared by introducing a phosphate ester group to the hydroxyl group at position 21 of the Dexamethasone molecule. Dexamethasone phosphate inhibits LPS (HY-D1056)-induced degradation of IRAK-1 and IRAK-4, and blocks LPS-induced activation of TRAF6, p-TAK1 and p-JNK. Dexamethasone phosphate inhibits the secretion of RANTES, TGF-β1 and NO, promotes the production of MIP-1α and IL-10, and blocks microglial migration. Dexamethasone phosphate is almost completely converted to Dexamethasone in rat blood, and supports transdermal delivery via iontophoresis. Dexamethasone phosphate can be used in research related to steroid-dependent ulcerative colitis, chemotherapy-induced vomiting, allergic asthma and acute colitis (inflammatory bowel disease) .

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14

Dexamethasone phosphate disodium

14 Cited Publications

Cat. No.: HY-B1829A

CAS No.: 2392-39-4

Synonyms: Dexamethasone 21-phosphate disodium

Target:

Glucocorticoid Receptor TGF-β Receptor Interleukin Related

Research Areas:

Neurological Disease Inflammation/Immunology

Dexamethasone phosphate (Dexamethasone 21-phosphate) disodium is a prodrug form of the glucocorticoid Dexamethasone (HY-14648). Dexamethasone phosphate disodium is produced by introducing a phosphate ester group at the 21-position of the Dexamethasone molecule, forming a salt with sodium ions, thereby significantly improving water solubility. Dexamethasone phosphate disodium inhibits LPS (HY-D1056)-induced degradation of IRAK-1 and IRAK-4, and blocks LPS-induced activation of TRAF6, p-TAK1 and p-JNK. Dexamethasone phosphate disodium inhibits the secretion of RANTES, TGF-β1 and NO, promotes the production of MIP-1α and IL-10, and blocks microglial migration. Dexamethasone phosphate disodium is almost completely converted to Dexamethasone in rat blood, and supports transdermal delivery via iontophoresis. Dexamethasone phosphate disodium can be used in research related to steroid-dependent ulcerative colitis, chemotherapy-induced vomiting, allergic asthma and acute colitis (inflammatory bowel disease) .

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6

Sodium acetate trihydrate, meets analytical specification of Ph. Eur. BP USP FCC E262, ≤0.00002% Al

6 Cited Publications

Cat. No.: HY-Y1325H

CAS No.: 6131-90-4

Sodium acetate trihydrate, meets analytical specification of Ph. Eur. BP USP FCC E262, ≤0.00002% Al is a carboxylic acid and short-chain fatty acid (SCFAs). Sodium acetate trihydrate activates AMPK, increases ROS, cleaved caspase 9, PPARα, downregulates SREBP-1c, ChREBP expression. Sodium acetate trihydrate exhibits antifungal activity against Saccharomyces cerevisiae W303-1A. Sodium acetate trihydrate regulates energy metabolism. Sodium acetate trihydrate has anticancer activity against gastric cancer. Sodium acetate trihydrate induces writhing reaction and ulcerative colitis. Sodium acetate trihydrate can be used in the researches for gastric cancer, ulcerative colitis, hepatic steatosis, and pain .

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5

BRD5529

5 Cited Publications

Cat. No.: HY-115497

CAS No.: 1358488-78-4

Purity: 98.94%

Target:

E1/E2/E3 Enzyme

Research Areas:

Infection Inflammation/Immunology

BRD5529 is an effective dose-dependent CARD9-TRIM62 protein–protein interaction (PPI) inhibitor with an IC₅₀ value of 8.6 μM. BRD5529 has potency and complete inhibition of CARD9 ubiquitinylation in vitro, also has favorable solubility. BRD5529 can be used for the research of inflammatory bowel disease (IBD) such as Crohn’s disease (CD) and ulcerative colitis (UC) .

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4

Vedolizumab

4 Cited Publications

Cat. No.: HY-P9911

CAS No.: 943609-66-3

Synonyms: Anti-Human lymphocyte α4β7 integrin, Humanized Antibody; LDP-02; MLN-002

Vedolizumab is a humanized IgG1 monoclonal antibody that targets the α4β7 integrin for the treatment of ulcerative colitis and Crohn's disease.

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4

Hydrocortisone hemisuccinate

4 Cited Publications

Cat. No.: HY-B1402

CAS No.: 2203-97-6

Synonyms: Hydrocortisone 21-hemisuccinate

Target:

Interleukin Related

Research Areas:

Cardiovascular Disease Metabolic Disease Inflammation/Immunology Endocrinology

Hydrocortisone hemisuccinate (Hydrocortisone 21-hemisuccinate), a glucocorticoid, is an orally active steroidal anti-inflammatory agent (SAID) with anti-inflammatory and immunomodulatory activities. Hydrocortisone hemisuccinate inhibits the bioactivity of IL-6 and IL-3 with IC₅₀ values of 6.7 and 21.4 μM, respectively. Hydrocortisone hemisuccinate can be used in the study of ulcerative colitis (UC) and recurrent oral ulcers .

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4

Vedolizumab (anti-α4β7-integrin)

4 Cited Publications

Cat. No.: HY-P9911A

CAS No.: 943609-66-3

Vedolizumab (anti-α4β7-integrin) is a humanized IgG1 monoclonal antibody that targets the α4β7 integrin for the treatment of ulcerative colitis and Crohn's disease .

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