59

Bedaquiline

59 Publications Verification

Cat. No.: HY-14881

CAS No.: 843663-66-1

Purity: 99.98%

Synonyms: TMC207; R207910

Target:

Bacterial Antibiotic

Research Areas:

Infection

Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit . Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

11

Carbenoxolone disodium

11 Cited Publications

Cat. No.: HY-B1367

CAS No.: 7421-40-1

Target:

Gap Junction Protein Orthopoxvirus 11β-HSD

Research Areas:

Infection Inflammation/Immunology

Carbenoxolone disodium is the active metabolite of Glycyrrhizic acid (HY-N0184) and the inhibitor of human 11β-HSD and bacterial 3α, 20β-HSD . Carbenoxolone disodium is an uncoupling agent for gap junctions and a potent inhibitor of Vaccinia virus replication . Carbenoxolone disodium is used for the study of peptic, esophageal and oral ulceration and inflammation. Carbenoxolone disodium inhibits Vaccinia virus replication.

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

9

Rafoxanide

9 Cited Publications

Cat. No.: HY-17598

CAS No.: 22662-39-1

Target:

Oxidative Phosphorylation Parasite p38 MAPK Raf Apoptosis

Research Areas:

Infection Cancer

Rafoxanide is a poent, orally active halogenated salicylaniline agent with antiparasitic activity. Rafoxanide interferes with energy metabolism in trematodes by uncoupling oxidative phosphorylation. Rafoxanide is also found to be a potent inhibitor of the BRAF V600E mutant protein, which is important in colorectal cancer. Rafoxanide can be used for the control of infestation with Hemonchus species or Fasciola species in sheep and cattle as well as Oestrus ovis in sheep. Rafoxanide can also be used for cancer research .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

6

EN6

6 Cited Publications

Cat. No.: HY-128892

CAS No.: 1808714-73-9

Purity: 99.42%

Target:

Autophagy

Research Areas:

Neurological Disease

EN6 is a small-molecule in vivo autophagy activator that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal v-ATPase. EN6-mediated modification of ATP6V1A uncouples v-ATPase from Rag, leading to inhibition of mTORC1 signalling, increased lysosomal acidification, and activation of autophagy. EN6 also scavenges TDP-43 aggregates (causative agents of frontotemporal dementia) in a lysosome-dependent manner .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

4

Oxyclozanide

4 Cited Publications

Cat. No.: HY-17594

CAS No.: 2277-92-1

Target:

Oxidative Phosphorylation Parasite Bacterial Fungal

Research Areas:

Infection

Oxyclozanide is an orally active salicylanilide anthelmintic agent that mainly acts by uncoupling oxidative phosphorylation in flukes. Oxyclozanide shows good anti-adenovirus, anti-biofilm, antifungal, and antibacterial activity .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

1

MS-L6

1 Cited Publications

Cat. No.: HY-158421

CAS No.: 63498-32-8

Purity: 99.95%

Target:

Oxidative Phosphorylation Mitochondrial Metabolism ATP Synthase Reactive Oxygen Species (ROS) Parasite

Research Areas:

Infection Cancer

MS-L6 is a OXPHOS inhibitor and antimalarial agent. MS-L6 inhibits NADH oxidation and electron transport. MS-L6 induces OXPHOS uncoupling, dissipates mitochondrial membrane potential, increases non-ATP-coupled oxygen consumption, and reduces ATP synthesis. MS-L6 triggers the production of ROS. MS-L6 exhibits anti-amoebic activity. MS-L6 exerts antitumor activity in mouse lymphoma xenograft models. MS-L6 can be used in research related to B-cell lymphoma, T-cell lymphoma, and non-Hodgkin B-cell lymphoma .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

Phenoxyethanol

Cat. No.: HY-B1729

CAS No.: 122-99-6

Target:

Bacterial Fungal Oxidative Phosphorylation

Research Areas:

Infection

Phenoxyethanol has a broad spectrum of antimicrobial agent. Phenoxyethanol is an uncouple agent in oxidative phosphorylation from respiration and competitively inhibits malate dehydrogenase. Phenoxyethanol is used as a preservative in cosmetic, vaccine, and textile, et al .

Compare

loading...

Please select quantity

August 31

Get Quote

View All Sizes

Benoxaprofen

Cat. No.: HY-13568

CAS No.: 51234-28-7

Purity: 99.24%

Synonyms: LRCL 3794

Target:

Cytochrome P450 COX Lipoxygenase PGE synthase

Research Areas:

Inflammation/Immunology

Benoxaprofen (LRCL 3794) is a nonsteroidal anti-inflammatory agent that blocks the biosynthesis of inflammatory mediators such as leukotrienes and prostaglandins by inhibiting 5-LOX, PGH2 synthase and cytochrome P-450. Benoxaprofen exhibits significant toxicity: it not only alters cellular redox status, uncouples oxidative phosphorylation and disrupts calcium ion homeostasis, but also causes liver injury through the formation of covalent adducts between its active metabolites and hepatic proteins. Benoxaprofen shows strong phototoxicity under ultraviolet irradiation, and induces erythrocyte lysis, mast cell degranulation and histamine release. Benoxaprofen is widely used in studies of urticaria and related phototoxic mechanisms .

Compare

loading...