4

Piboserod

4 Cited Publications

Cat. No.: HY-15574

CAS No.: 152811-62-6

Purity: 99.09%

Synonyms: SB-207266

Target:

5-HT Receptor

Research Areas:

Cardiovascular Disease

Piboserod is an orally available selective antagonist of the 5-HT4 receptor, with a K_i value of approximately 0.1 nM for human 5-HT4 receptors. Piboserod can competitively bind to the 5-HT4 receptor and block the activation of the 5-HT4 receptor. Piboserod can inhibit the enhancing effect of 5-HT on the nerve-mediated contraction response of the human bladder detrusor muscle. Piboserod is mainly used in the research of urinary system diseases (such as overactive bladder) and cardiovascular diseases (such as chronic heart failure) .

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Tolterodine

Cat. No.: HY-A0024

CAS No.: 124937-51-5

Synonyms: (R)-(+)-Tolterodine; (+)-Tolterodine; (R)-Tolterodine; PNU-200583

Target:

mAChR Cytochrome P450

Research Areas:

Neurological Disease Cancer

Tolterodine ((R)-(+)-Tolterodine) is a mAChR inhibitor and substrate for cytochrome P450 enzymes. Tolterodine competitively binds acetylcholine, reduces sympathetic excitation, and inhibits involuntary bladder muscle contraction. Tolterodine restores the Nrf2/NF-κB signaling pathway, mediates protection against inflammatory response and ferroptosis. Tolterodine ameliorates LPS (HY-D1056)-induced reactive oxygen species production and lipid oxidation. Tolterodine can be used for the research of urinary tract infections and overactive bladder .

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Tolterodine tartrate

Cat. No.: HY-90010

CAS No.: 124937-52-6

Synonyms: Kabi-2234; PNU-200583E

Target:

mAChR Cytochrome P450

Research Areas:

Neurological Disease Cancer

Tolterodine tartrate (Kabi-2234) is a mAChR inhibitor and substrate for cytochrome P450 enzymes. Tolterodine tartrate competitively binds acetylcholine, reduces sympathetic excitation, and inhibits involuntary bladder muscle contraction. Tolterodine tartrate restores the Nrf2/NF-κB signaling pathway, mediates protection against inflammatory response and ferroptosis. Tolterodine tartrate ameliorates LPS (HY-D1056)-induced reactive oxygen species production and lipid oxidation. Tolterodine tartrate can be used for the research of urinary tract infections and overactive bladder .

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(R)-Oxybutynin

Cat. No.: HY-B0267C

CAS No.: 119618-21-2

Synonyms: Aroxybutynin

Target:

mAChR

Research Areas:

Neurological Disease

(R)-Oxybutynin (Aroxybutynin), an enantiomer of Oxybutynin, is an orally active muscarinic receptor antagonist. (R)-Oxybutynin exhibits antispasmodic and anticholinergic activities, and competitively antagonizes carbachol-induced contractions. (R)-Oxybutynin can be used in the research of urinary incontinence caused by neurogenic bladder dysfunction .

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Prifinium bromide

Cat. No.: HY-122086

CAS No.: 4630-95-9

Target:

mAChR

Research Areas:

Neurological Disease

Prifinium bromide is an anticholinergic drug with anticholinergic and antispasmodic activities, and it exhibits oral activity. Prifinium bromide competitively antagonizes cholinergic receptors and relieves symptoms of spasm or hypermotility in the digestive and urinary tracts, with its anticholinergic activity representing the core mechanism underlying the inhibition of bladder smooth muscle contraction. Prifinium bromide can be used in research related to spasms and diverticular disease .

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(R)-Oxybutynin hydrochloride

Cat. No.: HY-B0267B

CAS No.: 1207344-05-5

Synonyms: Aroxybutynin hydrochloride

Target:

mAChR

Research Areas:

Neurological Disease

(R)-Oxybutynin hydrochloride (Aroxybutynin hydrochloride), an enantiomer of Oxybutynin hydrochloride, is an orally active muscarinic receptor antagonist. (R)-Oxybutynin hydrochloride exhibits antispasmodic and anticholinergic activities, and competitively antagonizes carbachol-induced contractions. (R)-Oxybutynin hydrochloride can be used in the research of urinary incontinence caused by neurogenic bladder dysfunction .

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TAK-259

Cat. No.: HY-120473

CAS No.: 1192348-73-4

Target:

Adrenergic Receptor

Research Areas:

Metabolic Disease

TAK-259 is an orally active α1D-adrenergic receptor antagonist with a K_i value of 1.1 nM for human α1D-adrenergic receptors. TAK-259 can inhibit the contraction of isolated bladder strips in rats with bladder outlet obstruction, reduce non-voiding bladder contractions, and improve urinary frequency symptoms. TAK-259 can be used in research related to overactive bladder .

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BMS-192364

Cat. No.: HY-114865

CAS No.: 202822-21-7

Purity: 99.01%

Target:

RGS Protein Calcium Channel

Research Areas:

Neurological Disease

BMS-192364 is targeting the G_α-RGS interaction to produce an inactive Gα-RGS complex. BMS-192364 reduces urinary bladder contraction and exert RGS-agonist properties by increasing the action of GAPs on Gq proteins. BMS-192364 inhibits calcium flux .

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