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31 Results for "

vATPase

" in MedChemExpress (MCE) Product Catalog:

Products (31)

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952

Bafilomycin A1

952 Publications Verification

Cat. No.: HY-100558

CAS No.: 88899-55-2

Purity: 99.95%

Synonyms: BafA1

Category:

Infection Microorganisms Macrolide Antibiotics Antibiotics Disease Research Anticancer Disease Research Fields

Target:

Proton Pump Autophagy Antibiotic Bacterial Apoptosis

Bafilomycin A1 (BafA1) is a specific and reversible inhibitor of vacuolar H ⁺-ATPase (V-ATPase) with IC₅₀ values of 4-400 nmol/mg. Bafilomycin A1, a macrolide antibiotic, is also used as an autophagy inhibitor at the late stage. Bafilomycin A1 blocks autophagosome-lysosome fusion and inhibits acidification and protein degradation in lysosomes of cultured cells. Bafilomycin A1 induces apoptosis .

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Concanamycin A

30 Cited Publications

Cat. No.: HY-N1724

CAS No.: 80890-47-7

Synonyms: Antibiotic X 4357B; Folimycin; X 4357B

Category:

Infection Natural Products Microorganisms Disease Research Fields

Target:

Proton Pump Bacterial Antibiotic

Concanamycin A (Folimycin; Antibiotic X 4357B) is a macrolide antibiotic, a vacuolar type H ⁺-ATPase (V-ATPase) inhibitor. Concanamycin A is also an inhibitor of lysosomal acidification, can be used to T cell-mediated inflammation research ^- .

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Concanamycin A (purity≥70%)

30 Cited Publications

Cat. No.: HY-N1724A

CAS No.: 80890-47-7

Synonyms: Antibiotic X 4357B (purity≥70%); Folimycin (purity≥70%); X 4357B (purity≥70%)

Category:

Microorganisms Antibiotics

Target:

Proton Pump Bacterial Antibiotic

Concanamycin A (purity≥70%) (Antibiotic X 4357B) is a macrolide antibiotic, a vacuolar type H ⁺-ATPase (V-ATPase) inhibitor. Concanamycin A (purity≥70%) is also an inhibitor of lysosomal acidification, can be used to T cell-mediated inflammation research ^- .

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EN6

6 Cited Publications

Cat. No.: HY-128892

CAS No.: 1808714-73-9

Purity: 99.42%

Target:

Autophagy

Research Areas:

Neurological Disease

EN6 is a small-molecule in vivo autophagy activator that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal v-ATPase. EN6-mediated modification of ATP6V1A uncouples v-ATPase from Rag, leading to inhibition of mTORC1 signalling, increased lysosomal acidification, and activation of autophagy. EN6 also scavenges TDP-43 aggregates (causative agents of frontotemporal dementia) in a lysosome-dependent manner .

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