3

CpG ODN 10101

3 Cited Publications

Cat. No.: HY-150217

CAS No.: 1234402-77-7

Synonyms: ODN 10101

Target:

Toll-like Receptor (TLR)

Research Areas:

Infection Inflammation/Immunology

CpG ODN 10101 (ODN 10101; CPG 10101) is a selective agonist targeting TLR9, a synthetic oligodeoxynucleotide modified with phosphate thioester. CpG ODN 10101 activates B cells and plasmacytoid dendritic cells (pDCs), inducing the production of cytokines and chemokines such as interferon-IFN-α, interferon-inducible protein IP-10, and 2'5'-oligoadenylate synthase (2'5'-OAS), regulating innate immunity and promoting Th1 adaptive immune responses. CpG ODN 10101 also possesses antiviral properties and enhances vaccine immunogenicity, making it suitable as an immunomodulator and vaccine adjuvant for vaccine development in chronic hepatitis C and infectious diseases such as melioidosis, pertussis, and respiratory syncytial virus (RSV) .

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1

COVID-19 Spike Protein mRNA(N1-Me-Pseudo UTP)

1 Cited Publications

Cat. No.: HY-153083

Target:

mRNA SARS-CoV

Research Areas:

Infection

COVID-19 Spike Protein mRNA (N1-Me-Pseudo UTP) is an mRNA encoding the SARS-CoV-2 spike protein with enhanced performance via chemical modification. COVID-19 Spike Protein mRNA (N1-Me-Pseudo UTP) replaces natural uridine (UTP) with N1-Me-Pseudo UTP, which effectively reduces immunogenicity and improves stability and translation efficiency. The 3' UTR of COVID-19 Spike Protein mRNA (N1-Me-Pseudo UTP) optimizes AU-rich elements through HuR anchor sites, exhibiting higher translation efficiency. COVID-19 Spike Protein mRNA is widely used in COVID-19-related scientific research and vaccine development .

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Dimethyldioctadecylammonium bromide

Cat. No.: HY-131119

CAS No.: 3700-67-2

Purity: ≥98.0%

Synonyms: Dioctadecyldimethylammonium bromide; DODAB

Target:

Liposome

Research Areas:

Others

Dimethyldioctadecylammonium bromide is a synthetic cationic lipid commonly used in gene delivery and vaccine development. Also known as DODAB or DDAB, it consists of a positively charged ammonium head group and two long hydrophobic tails. These properties make it useful for forming liposomes and other lipid-based nanoparticles that can efficiently deliver genetic material into cells. In addition to its applications in biotechnology, DDAB is also used in surfactants, emulsifiers and fabric softeners. However, due to its potential toxicity and irritation, extreme care should be taken when handling DDAB.

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OF-02

Cat. No.: HY-145795

CAS No.: 1883431-67-1

Purity: ≥98.0%

Target:

Liposome

Research Areas:

Others

OF-02 is an ionizable lipid for mRNA delivery and a key component of lipid nanoparticles (LNPs). OF-02 is protonated in the acidic endosomal environment to promote endosomal escape of mRNA and efficiently induce protein expression in target cells. OF-02 relies on the pH-responsive membrane fusion properties to form a complex with mRNA and destroy the endosomal membrane structure to achieve mRNA release in the cytoplasm. OF-02 is mainly used in the development of mRNA vaccines, gene editing, and protein replacement therapy[1][2][3].

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Schizophyllan

Cat. No.: HY-165126

CAS No.: 9050-67-3

Synonyms: SPG

Target:

C-type Lectin-like Receptors (CTLRs) Endogenous Metabolite Sirtuin JNK p38 MAPK PPAR AP-1

Research Areas:

Infection Metabolic Disease Inflammation/Immunology Cancer

Schizophyllan (SPG) is an orally active extracellular β-glucan produced by the fungus Schizophyllum commune. Schizophyllan improves mitochondrial function and protects against metabolic liver injury by activating the SIRT3 pathway. Schizophyllan inhibits osteoclastogenesis and promotes osteoblast differentiation by suppressing the phosphorylation of JNK/p38, as well as downregulating PGC1β/PPARγ, c-Fos and NFATc1. Recognized via Dectin-1, schizophyllan enables precise delivery of oligonucleotide drugs and antigens to antigen-presenting cells, thus holding great potential in the treatment of inflammatory diseases and vaccine development .

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Microsomal aminopeptidase, Microorganism

Cat. No.: HY-P2779

CAS No.: 9054-63-1

Target:

Endogenous Metabolite

Research Areas:

Metabolic Disease

Microsomal aminopeptidase, Microorganism is first reported from C. elegans. The Microsomal aminopeptidase, Microorganism is beneficial for the development of molecular vaccines against parasitic nematodes .

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OVA(250-264)

Cat. No.: HY-P11058

CAS No.: 355012-70-3

Synonyms: OVAp

Target:

MHC

Research Areas:

Cancer

OVA(250-264) (OVAvac) (OVAp) is an antigen peptide that can be from ovalbumin (OVA) presented by the class I MHC molecule, H-2Kb. OVA(250-264) combined withαMSLN (anti-MSLN antibody) significantly induces antigen-specific CD8 ⁺ T cell generation and infiltration for enhancing antitumor efficacy in orthotopic pancreatic cancer mice model. OVA(250-264) can be used for neoantigen vaccine development in pancreatic cancer immunotherapy research .

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