266

Angiotensin II human

266 Publications Verification

Cat. No.: HY-13948

CAS No.: 4474-91-3

Purity: 99.98%

Synonyms: Angiotensin II; Ang II; DRVYIHPF

Category:

Natural Products Endogenous metabolite Disease Research Fields Endocrinology Cancer

Target:

Angiotensin Receptor Apoptosis

Angiotensin II (Angiotensin II) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human also induces apoptosis. Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .

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266

Angiotensin II human acetate

266 Publications Verification

Cat. No.: HY-13948A

CAS No.: 68521-88-0

Purity: 99.62%

Synonyms: Angiotensin II acetate; Ang II acetate; DRVYIHPF acetate

Target:

Angiotensin Receptor Apoptosis

Research Areas:

Cardiovascular Disease Infection Metabolic Disease Inflammation/Immunology Cancer

Angiotensin II human (Angiotensin II) acetate is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human acetate plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human acetate stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human acetate induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human acetate also induces apoptosis. Angiotensin II human acetate induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .

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266

Angiotensin II human TFA

266 Publications Verification

Cat. No.: HY-13948B

CAS No.: 2761969-44-0

Purity: 98.84%

Synonyms: Angiotensin II TFA; Ang II TFA; DRVYIHPF TFA

Target:

Angiotensin Receptor Apoptosis

Research Areas:

Cardiovascular Disease Metabolic Disease Cancer

Angiotensin II human (Angiotensin II) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human TFA induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human TFA also induces apoptosis. Angiotensin II human TFA induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .

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83

Vadimezan

83 Cited Publications

Cat. No.: HY-10964

CAS No.: 117570-53-3

Purity: 99.93%

Synonyms: DMXAA; ASA-404

Target:

STING IFNAR Influenza Virus

Research Areas:

Infection Cancer

Vadimezan (DMXAA), the tumor vascular disrupting agent (tumor-VDA), is a murine agonist of the stimulator of interferon genes (STING) and also a potent inducer of type I IFNs and other cytokines. Vadimezan is unable to activate human STING. Vadimezan has anti-influenza virus H1N1-PR8 activities.

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45

C16-PAF

45 Cited Publications

Cat. No.: HY-108635

CAS No.: 74389-68-7

Purity: 99.85%

Synonyms: PAF (C16)

Category:

Human Gut Microbiota Metabolites Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

p38 MAPK MEK ERK Endogenous Metabolite

C16-PAF (PAF (C16)), a phospholipid mediator, is a platelet-activating factor and ligand for PAF G-protein-coupled receptor (PAFR). C16-PAF exhibits anti-apoptotic effect and inhibits caspase-dependent death by activating the PAFR. C16-PAF is a potent MAPK and MEK/ERK activator. C16-PAF induces increased vascular permeability .

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35

β-Glycerophosphate disodium salt hydrate

35 Cited Publications

Cat. No.: HY-126304

CAS No.: 154804-51-0

Purity: ≥98.0%

Category:

Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

Phosphatase Endogenous Metabolite ERK

β-Glycerophosphate disodium salt pentahydrate is a bioactive endogenous metabolite and a phosphatase inhibitor. β-Glycerophosphate disodium salt pentahydrate plays an important role in inducing and maintaining osteoblast differentiation, mineral metabolism and signal transduction, and can be used as a drug carrier to form heat-sensitive hydrogels. β-Glycerophosphate disodium salt hydrate accelerates the calcification of vascular smooth muscle cells .

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35

β-Glycerophosphate disodium salt pentahydrate

35 Cited Publications

Cat. No.: HY-D0886

CAS No.: 13408-09-8

Category:

Natural Products Neurological Disease Endogenous metabolite Disease Research Fields Cancer

Target:

Phosphatase Endogenous Metabolite ERK

β-Glycerophosphate disodium salt pentahydrate is a bioactive endogenous metabolite and a phosphatase inhibitor. β-Glycerophosphate disodium salt pentahydrate plays an important role in inducing and maintaining osteoblast differentiation, mineral metabolism and signal transduction, and can be used as a drug carrier to form heat-sensitive hydrogels. β-Glycerophosphate disodium salt hydrate accelerates the calcification of vascular smooth muscle cells .

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33

Clopidogrel

33 Cited Publications

Cat. No.: HY-15283

CAS No.: 113665-84-2

Purity: 99.13%

Synonyms: Clopidogrelum

Target:

P2Y Receptor

Research Areas:

Cardiovascular Disease Cancer

Clopidogrel is an orally active platelet inhibitor that targets P2Y12 receptor. Clopidogrel is used to inhibit blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease.

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33

Eicosapentaenoic Acid

33 Cited Publications

Cat. No.: HY-B0660

CAS No.: 10417-94-4

Synonyms: EPA; Timnodonic acid

Category:

Human Gut Microbiota Metabolites Neurological Disease Ketones, Aldehydes, Acids Marine natural products Endogenous metabolite Disease Research Fields Cancer

Target:

Endogenous Metabolite Histone Demethylase

Eicosapentaenoic Acid (EPA) is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid can promote relaxation of vascular smooth muscle cells and vasodilation .

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33

Eicosapentaenoic Acid sodium

33 Cited Publications

Cat. No.: HY-W011269

CAS No.: 73167-03-0

Synonyms: EPA sodium; Timnodonic acid sodium

Category:

Cardiovascular Disease Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields

Target:

Endogenous Metabolite Histone Demethylase

Eicosapentaenoic Acid (EPA)sodium is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid sodium exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid sodium activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid sodium can promote relaxation of vascular smooth muscle cells and vasodilation .

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32

PF-562271

32 Cited Publications

Cat. No.: HY-10459

CAS No.: 717907-75-0

Purity: 99.68%

Synonyms: VS-6062

Target:

FAK Pyk2

PF-562271 (VS-6062) is an orally active, ATP-competitive, reversible FAK/Pyk2 inhibitor, with an IC₅₀ of 1.5 nM for FAK and 13 nM for Pyk2. PF-562271 induces tumor regression, and inhibits tumor growth, invasion and metastasis. PF-562271 exerts no effect on tumor necrosis, angiogenesis or apoptosis in an orthotopic mouse model of pancreatic ductal adenocarcinoma. When combined with Sunitinib (HY-10255A), PF-562271 reduces tumor vascularization, decreases serum alpha-fetoprotein levels and improves cachexia. PF-562271 can be used in research related to prostate cancer, breast cancer, pancreatic cancer, colon cancer, glioblastoma, lung cancer, pancreatic ductal adenocarcinoma and hepatocellular carcinoma .

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32

PF-562271 (besylate)

32 Cited Publications

Cat. No.: HY-10458

CAS No.: 939791-38-5

Purity: 99.17%

Synonyms: VS-6062 (besylate)

Target:

FAK Pyk2

PF-562271 besylate (VS-6062 besylate) is an orally active, ATP-competitive, reversible FAK/Pyk2 inhibitor, with an IC₅₀ of 1.5 nM for FAK and 13 nM for Pyk2. PF-562271 besylate induces tumor regression, and inhibits tumor growth, invasion and metastasis. PF-562271 besylate exerts no effect on tumor necrosis, angiogenesis or apoptosis in an orthotopic mouse model of pancreatic ductal adenocarcinoma. When combined with Sunitinib (HY-10255A), PF-562271 besylate reduces tumor vascularization, decreases serum alpha-fetoprotein levels and improves cachexia. PF-562271 besylate can be used in research related to prostate cancer, breast cancer, pancreatic cancer, colon cancer, glioblastoma, lung cancer, pancreatic ductal adenocarcinoma and hepatocellular carcinoma .

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30

PF-562271 hydrochloride

30 Cited Publications

Cat. No.: HY-20403

CAS No.: 939791-41-0

Synonyms: VS-6062hydrochloride

Target:

FAK Pyk2

PF-562271 hydrochloride (VS-6062 hydrochloride) is an orally active, ATP-competitive, reversible FAK/Pyk2 inhibitor, with an IC₅₀ of 1.5 nM for FAK and 13 nM for Pyk2. PF-562271 hydrochloride induces tumor regression, and inhibits tumor growth, invasion and metastasis. PF-562271 hydrochloride exerts no effect on tumor necrosis, angiogenesis or apoptosis in an orthotopic mouse model of pancreatic ductal adenocarcinoma. When combined with Sunitinib (HY-10255A), PF-562271 hydrochloride reduces tumor vascularization, decreases serum alpha-fetoprotein levels and improves cachexia. PF-562271 hydrochloride can be used in research related to prostate cancer, breast cancer, pancreatic cancer, colon cancer, glioblastoma, lung cancer, pancreatic ductal adenocarcinoma and hepatocellular carcinoma .

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27

L-Arginine

27 Cited Publications

Cat. No.: HY-N0455

CAS No.: 74-79-3

Category:

Cardiovascular Disease Amino acids Endogenous metabolite Disease Research Fields Cancer

Target:

NO Synthase Endogenous Metabolite

L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

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27

L-Arginine hydrochloride

27 Cited Publications

Cat. No.: HY-N0455A

CAS No.: 1119-34-2

Synonyms: (S)-(+)-Arginine hydrochloride

Category:

Natural Products Other Diseases Endogenous metabolite Disease Research Fields

Target:

NO Synthase Endogenous Metabolite

L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis .

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