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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
vasculopathies
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "vasculopathies" in MCE Product Catalog:
Cat. No.: HY-P99830
CAS No.: 1227158-72-6
Synonyms: KH902
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Cat. No.: HY-123187
CAS No.: 1251906-10-1
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AS2553627 is a type of JAK inhibitor, with IC50 values of 0.46, 0.30, 0.14, and 2.0 nM for JAK1, JAK2, JAK3 and TYK2, respectively. AS2553627 can inhibit the proliferation of human and rat T cells stimulated by IL-2, with IC50 values of 2.4 and 4.3 nM, respectively. AS2553627 can reduce cardiac allograft vasculopathy and fibrosis in a rat heart transplant model, effectively extending survival rates. AS2553627 can be used to prevent acute and chronic rejection in heart transplants .
Cat. No.: HY-156049
CAS No.: 149204-50-2
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MG-H1 is a RAGE ligand, advanced glycation end product cross-link, and pathogenic mediator with relevance to diabetic vasculopathy. MG-H1 binds to RAGE and competes with CM1 for RAGE binding on endothelial cells. MG-H1 is implicated in diabetic vasculopathy pathogenesis. MG-H1 can be used for the research of diabetic vasculopathy .
Cat. No.: HY-178049A
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UM-259 hydrochloride is a STING inhibitor with activity against both murine and human STING (including the STING R232 mutant). UM-259 hydrochloride inhibits STING-dependent signaling pathways, blocks STING oligomerization, and acts on human primary CD14 + monocytes. UM-259 hydrochloride can be used for research on amyotrophic lateral sclerosis, lupus erythematosus, Aicardi-Goutières syndrome, and infant-onset STING-associated vasculopathy .
Cat. No.: HY-118854
CAS No.: 36981-91-6
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Fepradinol is an orally active nonsteroidal anti-inflammatory agent. Fepradinol inhibits the increase in vascular permeability induced by histamine, 5-hydroxytryptamine, and bradykinin, reduces exudate volume, prevents leukocyte migration, and suppresses acute inflammation models. Fepradinol also induces thrombotic vasculopathy with epidermal necrosis, without leukocytoclastic vasculitis; triggers occlusive contact dermatitis presenting as purpuric papulonecrotic lesions, and causes strongly positive patch test reactions. Fepradinol can be used in research related to occlusive contact dermatitis and acute inflammation .
Cat. No.: HY-118854B
CAS No.: 67704-50-1
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Fepradinol hydrochloride is an orally active nonsteroidal anti-inflammatory agent. Fepradinol hydrochloride inhibits the increase in vascular permeability induced by histamine, 5-hydroxytryptamine, and bradykinin, reduces exudate volume, prevents leukocyte migration, and suppresses acute inflammation models. Fepradinol hydrochloride also induces thrombotic vasculopathy with epidermal necrosis, without leukocytoclastic vasculitis; triggers occlusive contact dermatitis presenting as purpuric papulonecrotic lesions, and causes strongly positive patch test reactions. Fepradinol hydrochloride can be used in research related to occlusive contact dermatitis and acute inflammation .
Cat. No.: HY-118854A
CAS No.: 1185076-47-4
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Fepradinol oxalate is an orally active nonsteroidal anti-inflammatory agent. Fepradinol oxalate inhibits the increase in vascular permeability induced by histamine, 5-hydroxytryptamine, and bradykinin, reduces exudate volume, prevents leukocyte migration, and suppresses acute inflammation models. Fepradinol oxalate also induces thrombotic vasculopathy with epidermal necrosis, without leukocytoclastic vasculitis; triggers occlusive contact dermatitis presenting as purpuric papulonecrotic lesions, and causes strongly positive patch test reactions. Fepradinol oxalate can be used in research related to occlusive contact dermatitis and acute inflammation .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
