11

Minoxidil

11 Publications Verification

Cat. No.: HY-B0112

CAS No.: 38304-91-5

Synonyms: U10858

Category:

Cardiovascular Disease Disease Research Fields Cancer

Target:

Potassium Channel

Minoxidil (U10858) is an ATP-sensitive potassium (K_ATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil is also a potent inhibitor of soybean lipoxygenaseare with an IC₅₀ of 20 μM .

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4

Regadenoson

4 Cited Publications

Cat. No.: HY-A0168

CAS No.: 313348-27-5

Synonyms: CVT-3146

Target:

Adenosine Receptor

Research Areas:

Cardiovascular Disease Cancer

Regadenoson (CVT-3146) is a selective A2A adenosine receptor agonist and vasodilator that increases coronary blood flow, can be used in study of myocardial perfusion imaging. Regadenoson also increases the permeability of the blood-brain barrier (BBB) in rodents, can be used to study increased delivery of agents to the human CNS .

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2

Isradipine

2 Cited Publications

Cat. No.: HY-B0233

CAS No.: 75695-93-1

Synonyms: PN 200-110

Target:

Calcium Channel Autophagy

Research Areas:

Cardiovascular Disease Neurological Disease

Isradipine (PN 200-110) is an orally active and blood-brain barrier permeability L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease .

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1

Diphylline

1 Cited Publications

Cat. No.: HY-B0128

CAS No.: 479-18-5

Synonyms: Diprophylline

Target:

Adenosine Receptor Phosphodiesterase (PDE)

Research Areas:

Cardiovascular Disease Inflammation/Immunology

Diphylline (Diprophylline) is a potent A1/A2 adenosine receptor antagonist and cyclic nucleotide phosphodiesterase inhibitor. Diphylline, a xanthine derivative, is a bronchodilator and vasodilator agent and has the potential for chronic bronchitis and emphysema .

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1

Molsidomine

1 Cited Publications

Cat. No.: HY-B1069

CAS No.: 25717-80-0

Synonyms: SIN-10; Morsydomine

Target:

Drug Metabolite

Research Areas:

Cardiovascular Disease Neurological Disease Metabolic Disease

Molsidomine, a nitric oxide (NO) donor, is an orally active vasodilator agent. Molsidomine is a prodrug that can be rapidly metabolized in the liver to its active metabolite, Linsidomine (HY-101200). Molsidomine can be used for the study of angina pectoris, mental disorders and diabetic complications .

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Amrinone

Cat. No.: HY-B1294

CAS No.: 60719-84-8

Synonyms: Inamrinone

Target:

Phosphodiesterase (PDE)

Research Areas:

Cardiovascular Disease

Amrinone (Inamrinone) is a positive inotropic-vasodilator agent. Amrinone is a selective phosphodiesterase III inhibitor that increases cyclic adenosine monophosphate by preventing its breakdown. Amrinone is also an orally active, non-glycosidic and non-catecholamine cardiotonic agent .

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Eperisone hydrochloride

Cat. No.: HY-B1901

CAS No.: 56839-43-1

Synonyms: (±)-Eperisone hydrochloride

Target:

P2X Receptor

Research Areas:

Neurological Disease

Eperisone Hydrochloride ((±)-Eperisone hydrochloride) is an orally active antispastic agent with a vasodilator effect, used for the research of muscle stiffness and pain. Eperisone Hydrochloride is a potent and selectively P2X7 receptor antagonist, also shows antagonism for human P2X3. Eperisone Hydrochloride works by relaxing both skeletal muscles and vascularsmooth muscles, demonstrating a variety of effects such as reduction ofmyotonia, improvement of circulationand and suppression of the pain reflex .

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Trapidil

Cat. No.: HY-B1016

CAS No.: 15421-84-8

Synonyms: AR-12008

Target:

PDGFR Phosphodiesterase (PDE) Prostaglandin Receptor

Research Areas:

Cardiovascular Disease Neurological Disease

Trapidil (AR-12008) is an orally active vasodilator and antiplatelet agent. Trapidil antagonizes platelet-derived growth factor (PDGF), inhibits phosphodiesterase, thromboxane A₂ synthesis and pro-inflammatory cytokine production. Trapidil promotes prostacyclin biosynthesis, reduces lipid peroxidation, regulates nitric oxide metabolism, and inhibits cell proliferation and migration. Trapidil exerts tissue-protective effects, regulates bone turnover, and inhibits pyroptosis via the GPX3/Nrf2 pathway. Trapidil is applicable to research related to renal ischemia-reperfusion injury, chronic stable angina, restenosis, meningioma, diabetic cardiomyopathy and peripheral nerve crush injury .

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Minoxidil (Standard)

Cat. No.: HY-B0112R

CAS No.: 38304-91-5

Synonyms: U10858 (Standard)

Category:

Alkaloids Piperidine Alkaloids Endogenous metabolite

Target:

Reference Standards Potassium Channel Endogenous Metabolite

Minoxidil (Standard) is the analytical standard of Minoxidil. This product is intended for research and analytical applications. Minoxidil (U10858) is an ATP-sensitive potassium (KATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil is also a potent inhibitor of soybean lipoxygenaseare with an IC50 of 20 μM .

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Dihydralazine sulfate

Cat. No.: HY-N7065

CAS No.: 7327-87-9

Target:

Drug Derivative

Research Areas:

Cardiovascular Disease Neurological Disease

Dihydralazine sulfate is an antihypertensive hydrazine derivative and also a low-potency genotoxic agent. Dihydralazine sulfate is a direct-acting mutagen with a mixed gene mutation mechanism, which induces DNA fragmentation in the lung, kidney and spleen of mice, and induces sister chromatid exchange in mouse bone marrow cells. Dihydralazine sulfate specifically kills DNA repair-deficient bacteria. Dihydralazine sulfate is a vasodilator and antihypertensive agent that reduces systemic vascular resistance, increases cardiac output and heart rate, thereby lowering blood pressure. Dihydralazine sulfate can be used in research related to hypertension and severe early-onset preeclampsia .

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Minoxidil-d10

Cat. No.: HY-23196S

CAS No.: 1020718-66-4

Minoxidil-d₁₀ (U10858-d10) is the deuterium labeled Minoxidil. Minoxidil (U10858) is an ATP-sensitive potassium (KATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil is also a potent inhibitor of soybean lipoxygenaseare with an IC50 of 20 μM[1][2][3].

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Gallopamil hydrochloride

Cat. No.: HY-14276A

CAS No.: 16662-46-7

Purity: 98.10%

Synonyms: Methoxyverapamil hydrochloride

Target:

Calcium Channel

Research Areas:

Cardiovascular Disease

Gallopamil hydrochloride (Methoxyverapamil hydrochloride), a methoxy derivative of Verapamil, is a phenylalkylamine calcium antagonist . Gallopamil hydrochloride inhibits acid secretion in a concentration-dependent manner with an IC₅₀ of 10.9 μM . Gallopamil hydrochloride is a potent antiarrhythmic and vasodilator agent .

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Quinaprilat

Cat. No.: HY-127026

CAS No.: 82768-85-2

Target:

Angiotensin-converting Enzyme (ACE)

Research Areas:

Cardiovascular Disease

Quinaprilat is an orally active non-mercapto Angiotensin Converting Enzyme (ACE) inhibitor, the active metabolite of Quinapril. Quinaprilat specifically blocks the conversion of angiotensin I to the vasoconstrictor angiotensin II and inhibits the degradation of bradykinin. Quinaprilat acts as anti-hypertensive agent and vasodilator .

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Buflomedil hydrochloride

Cat. No.: HY-B0484

CAS No.: 35543-24-9

Target:

Adrenergic Receptor

Research Areas:

Cardiovascular Disease

Buflomedil hydrochloride, a vasodilator agent, is an orally active α1A-adrenoceptor antagonist with K_is of 4.06 µM and 6.84 µM for α1A-AR and α1B-AR, respectively. Buflomedil hydrochloride can be used for the study of peripheral circulatory disorders .

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Phytolaccagenin

Cat. No.: HY-N1433

CAS No.: 1802-12-6

Category:

Phytolaccaceae Extract Triterpenes Terpenoids 500 - Internal Server Error | MedChemExpress

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vasodilator agent

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