14

14 Publications Verification

Synonyms: YM 087

Target:

Conivaptan hydrochloride (YM 087) is an orally active dual vasopressin V_1a/V₂ receptor antagonist with K_i values of 0.48 nM and 3.04 nM for vasopressin V_1a receptor and V₂ receptor, respectively. Conivaptan hydrochloride competitively and reversibly blocks vasopressin-mediated antidiuresis, vasoconstriction, and cellular hypertrophy, while inhibiting CYP3A4. Conivaptan hydrochloride inhibits vasopressin-induced intracellular calcium, cAMP, and mitogen-activated kinase activation in vascular smooth muscle cells and cardiomyocytes. Conivaptan hydrochloride induces water diuresis while improving hemodynamics in heart failure models, reducing left ventricular end-diastolic pressure, vascular resistance, and organ weight. Conivaptan hydrochloride is used for research on hyponatremia and congestive heart failure .

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4

Nitrendipine

4 Cited Publications

Cat. No.: HY-B0424

CAS No.: 39562-70-4

Synonyms: BAY-E-5009

Target:

Calcium Channel Apoptosis

Research Areas:

Cardiovascular Disease Neurological Disease Cancer

Nitrendipine (BAY-E-5009) is an orally active analog of Nifedipine (HY-B0284) and dihydropyridine calcium channel blocker. Nitrendipine induces Apoptosis. Nitrendipine has antihypertensive effects. Nitrendipine blocks alcohol and Morphine withdrawal symptoms. Nitrendipine reduces right ventricular hypertrophy and pulmonary vascular changes induced by intermittent hypoxia. Nitrendipine has anticancer effects on neuroblastoma .

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3

Manidipine

3 Cited Publications

Cat. No.: HY-B0419

CAS No.: 89226-50-6

Target:

Calcium Channel Interleukin Related

Research Areas:

Cardiovascular Disease Neurological Disease Endocrinology

Manidipine is an orally active calcium channel antagonist. Manidipine regulates the expression of cytokines (IL-1β, IL-6). Manidipine has a hypotensive effect. Manidipine can be used in the study of cardiovascular diseases (such as hypertension, myocardial ischemia-reperfusion injury, ventricular hypertrophy), kidney diseases (such as glomerular diseases), and epilepsy .

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1

Indapamide

1 Cited Publications

Cat. No.: HY-B0259

CAS No.: 26807-65-8

Target:

Potassium Channel

Research Areas:

Cardiovascular Disease

Indapamide is an orally active sulphonamide diuretic agent, that can reduce blood pressure by decreasing vascular reactivity and peripheral vascular resistance. Indapamide is also can reduce left ventricular hypertrophy .

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1

Xipamide

1 Cited Publications

Cat. No.: HY-W042301

CAS No.: 14293-44-8

Target:

Anion Exchangers Carbonic Anhydrase Endothelin Receptor

Research Areas:

Cardiovascular Disease

Xipamide is an orally active carbonic anhydrase (CA) inhibitor and Na ⁺/Cl ^--potassium transporter inhibitor with diuretic and antihypertensive effects. Xipamide reduces NaCl reabsorption by inhibiting the Cl ^-/NaCO₃ ^- anion exchanger, and increases calcium reabsorption while promoting potassium and magnesium excretion. Xipamide is mainly cleared via the renal pathway and causes a temporary decrease in glomerular filtration rate under specific conditions. Xipamide does not affect Ca ²⁺ signaling induced by endothelin-1 and other factors, nor does it inhibit various ion cotransport or pump activities in red blood cells. Xipamide can be used in researches related to cardiovascular diseases, hypertension (especially with left ventricular hypertrophy), advanced renal failure, and liver cirrhosis with ascites .

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Delocamten

Cat. No.: HY-172424

CAS No.: 2417411-02-8

Target:

Myosin

Research Areas:

Cardiovascular Disease

Delocamten is an orally active, selective Cardiac Myosin inhibitor with an IC₅₀ of approximately 1.11 μM. Delocamten directly modulates myosin complexes, inhibits excessive myocardial contraction, and improves diastolic function. Delocamten can be used in studies of hypertrophic cardiomyopathy (HCM), left ventricular hypertrophy, and diastolic dysfunction .

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Nitrendipine-d5

Cat. No.: HY-B0424S

CAS No.: 2469554-26-3

Synonyms: AY-E-5009-d₅

Nitrendipine-d₅ is the deuterium labeled Nitrendipine (HY-B0424). Nitrendipine (BAY-E-5009) is an orally active analog of Nifedipine (HY-B0284) and dihydropyridine calcium channel blocker. Nitrendipine induces Apoptosis. Nitrendipine has antihypertensive effects. Nitrendipine blocks alcohol and Morphine withdrawal symptoms. Nitrendipine reduces right ventricular hypertrophy and pulmonary vascular changes induced by intermittent hypoxia. Nitrendipine has anticancer effects on neuroblastoma .

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Conivaptan

Cat. No.: HY-18347

CAS No.: 210101-16-9

Synonyms: YM 087 free base

Target:

Vasopressin Receptor Cytochrome P450

Research Areas:

Cardiovascular Disease Metabolic Disease

Conivaptan (YM 087 free base) is an orally active dual vasopressin V_1a/V₂ receptor antagonist with K_i values of 0.48 nM and 3.04 nM for vasopressin V_1a receptor and V₂ receptor, respectively. Conivaptan competitively and reversibly blocks vasopressin-mediated antidiuresis, vasoconstriction, and cellular hypertrophy, while inhibiting CYP3A4. Conivaptan inhibits vasopressin-induced intracellular calcium, cAMP, and mitogen-activated kinase activation in vascular smooth muscle cells and cardiomyocytes. Conivaptan induces water diuresis while improving hemodynamics in heart failure models, reducing left ventricular end-diastolic pressure, vascular resistance, and organ weight. Conivaptan is used for research on hyponatremia and congestive heart failure .

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KS370G

Cat. No.: HY-114683

CAS No.: 105955-01-9

Purity: 99.71%

Target:

TGF-beta/Smad

Research Areas:

Cardiovascular Disease

KS370G is an orally active hypoglycemic and cardiovascular protective agent. KS370G improves left ventricular hypertrophy and function in pressure-overload mice heart. KS370G reduces renal obstructive nephropathy .

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Indapamide (Standard)

Cat. No.: HY-B0259R

CAS No.: 26807-65-8

Target:

Reference Standards Potassium Channel

Research Areas:

Cardiovascular Disease

Indapamide (Standard) is the analytical standard of Indapamide. This product is intended for research and analytical applications. Indapamide is an orally active sulphonamide diuretic agent, that can reduce blood pressure by decreasing vascular reactivity and peripheral vascular resistance. Indapamide is also can reduce left ventricular hypertrophy .

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Nitrendipine (Standard)

Cat. No.: HY-B0424R

CAS No.: 39562-70-4

Synonyms: BAY-E-5009 (Standard)

Target:

Reference Standards Calcium Channel Apoptosis

Research Areas:

Cardiovascular Disease Neurological Disease Cancer

Nitrendipine (Standard) is the analytical standard of Nitrendipine (HY-B0424). This product is intended for research and analytical applications. Nitrendipine (BAY-E-5009) is an orally active analog of Nifedipine (HY-B0284) and dihydropyridine calcium channel blocker. Nitrendipine induces Apoptosis. Nitrendipine has antihypertensive effects. Nitrendipine blocks alcohol and Morphine withdrawal symptoms. Nitrendipine reduces right ventricular hypertrophy and pulmonary vascular changes induced by intermittent hypoxia. Nitrendipine has anticancer effects on neuroblastoma .

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L-3373

Cat. No.: HY-116478

CAS No.: 1951-26-4

Target:

Potassium Channel

Research Areas:

Others

L-3373 is a voltage-dependent potassium channel inhibitor with activity that reduces the effective refractory period and the dispersion of monophasic action potential duration, while significantly reducing susceptibility to ventricular fibrillation in a cat model of left ventricular hypertrophy.

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(rac)-Indapamide-d3

Cat. No.: HY-B0259S

CAS No.: 1217052-38-4

(rac)-Indapamide-d₃ is a labelled racemic Indapamide. Indapamide is an orally active sulphonamide diuretic agent, that can reduce blood pressure by decreasing vascular reactivity and peripheral vascular resistance. Indapamide is also can reduce left ventricular hypertrophy .

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AC-SDKP-NH2

Cat. No.: HY-P11297

CAS No.: 194484-75-8

Target:

Angiotensin-converting Enzyme (ACE)

Research Areas:

Cardiovascular Disease

AC-SDKP-NH2 is a substrate peptide of Angiotensin converting enzyme (ACE). AC-SDKP-NH2 has anti-inflammatory and anti-fibrotic activities. AC-SDKP-NH2 directly acts on tissues and prevents or reverses them from excessive fibrosis, but fails to reduce blood pressure and left ventricular hypertrophy (LVH). AC-SDKP-NH2 attenuates inflammation and cell differentiation, proliferation and migration, therefore reducing fibrosis in the heart, vessels and kidneys in mice model. AC-SDKP-NH2 can be used for cardiovascular diseases such as hypertension research .

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