230

Remdesivir

230 Publications Verification

Cat. No.: HY-104077

CAS No.: 1809249-37-3

Purity: 99.95%

Synonyms: GS-5734

Target:

DNA/RNA Synthesis SARS-CoV

Research Areas:

Infection

Remdesivir (GS-5734) is a nucleoside analogue with effective antiviral activity. Remdesivir can inhibit the synthesis of viral DNA or RNA. Remdesivir can be used for the research of infection, such as SARS-CoV and MHV infection .

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89

Indomethacin

89 Cited Publications

Cat. No.: HY-14397

CAS No.: 53-86-1

Purity: 99.91%

Synonyms: Indometacin

Target:

COX Antibiotic Influenza Virus Bacterial

Research Areas:

Infection Neurological Disease Inflammation/Immunology Cancer

Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC₅₀ values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin has anticancer activity and anti-infective activity. Indomethacin can be used for cancer, inflammation and viral infection research .

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89

Indomethacin sodium hydrate

89 Cited Publications

Cat. No.: HY-14397A

CAS No.: 74252-25-8

Purity: 99.85%

Synonyms: Indometacin sodium hydrate

Target:

COX Bacterial Influenza Virus Antibiotic

Research Areas:

Infection Neurological Disease Inflammation/Immunology Cancer

Indomethacin (Indometacin) sodium hydrateis a orally active and BBB-permeable COX1/2 inhibitor with IC₅₀ values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin sodium hydrateis has anticancer activity and anti-infective activity. Indomethacin sodium hydrateis can be used for cancer, inflammation and viral infection research .

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55

Favipiravir

55 Cited Publications

Cat. No.: HY-14768

CAS No.: 259793-96-9

Purity: 99.97%

Synonyms: T-705

Target:

DNA/RNA Synthesis Influenza Virus SARS-CoV Bacterial

Research Areas:

Infection

Favipiravir (T-705) is a potent viral RNA polymerase inhibitor, it is phosphoribosylated by cellular enzymes to its active form, Favipiravir-ribofuranosyl-5′-triphosphate (RTP). Favipiravir-RTP inhibits the influenza viral RNA-dependent RNA polymerase (RdRP) activity with an IC₅₀ of 341 nM.

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55

Baloxavir

55 Cited Publications

Cat. No.: HY-109025A

CAS No.: 1985605-59-1

Purity: 99.68%

Synonyms: Baloxavir acid; S-033447

Target:

Influenza Virus

Research Areas:

Infection Cancer

Baloxavir (Baloxavir acid), derived from the proagent Baloxavir marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir inhibits viral RNA transcription and replication and has potently antiviral activity .

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44

Bardoxolone methyl

44 Cited Publications

Cat. No.: HY-13324

CAS No.: 218600-53-4

Purity: 98.92%

Synonyms: RTA 402; NSC 713200; CDDO Methyl ester

Target:

Keap1-Nrf2 SARS-CoV Virus Protease

Research Areas:

Infection Neurological Disease Inflammation/Immunology

Bardoxolone methyl (RTA 402) is an orally active and blood-brain-barrier-penetrant activator of Nrf2 and an inhibitor of SARS-CoV-2 3CL protease. Bardoxolone methyl inhibits SARS-CoV-2 replication in Vero cells with an EC₅₀ value of 0.29 μM. Bardoxolone methyl increases levels of pNrf2 and HO-1, inhibits inflammatory mediators like pNFκB and MCP-1. Bardoxolone methyl activates the Nrf2 pathway to enhance antioxidant and anti-inflammatory responses, inhibits viral replication, and improves mitochondrial function. Bardoxolone methyl can be used in research on chemotherapy-induced neuropathic pain (CINP), COVID-19, and chronic kidney disease (CKD) .

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40

Paquinimod

40 Cited Publications

Cat. No.: HY-100442

CAS No.: 248282-01-1

Purity: 99.90%

Synonyms: ABR-215757; ABR 25757

Target:

SARS-CoV

Research Areas:

Metabolic Disease Inflammation/Immunology

Paquinimod (ABR 215757) is a specific and orally active inhibitor of S100A8/S100A9. Paquinimod rescues the pneumonia with substantial reduction of viral loads in SARS-CoV-2-infected mice .

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38

SC75741

38 Cited Publications

Cat. No.: HY-10496

CAS No.: 913822-46-5

Purity: 99.24%

Target:

NF-κB Influenza Virus

Research Areas:

Infection Cancer

SC75741 is a broad and efficient NF-κB inhibitor with an IC₅₀ of 200 nM for p65 . SC75741 blocks influenza viruses (IV) replication. SC75741 impairs DNA binding of the NF-κB subunit p65, resulting in reduced expression of cytokines, chemokines, and pro-apoptotic factors. SC75741 subsequently inhibits caspase activation and blocks caspase-mediated nuclear export of viral ribonucleoproteins .

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38

OSS_128167

38 Cited Publications

Cat. No.: HY-107454

CAS No.: 887686-02-4

Purity: 98.63%

Target:

Sirtuin HBV

Research Areas:

Infection Metabolic Disease Inflammation/Immunology Cancer

OSS_128167 is a potent selective sirtuin 6 (SIRT6) inhibitor with IC₅₀s of 89 μM, 1578 μM and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-HBV activity that inhibits HBV transcription and replication. OSS_128167 has anti-cancer, anti-inflammation and anti-viral effects .

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38

Dolutegravir

38 Cited Publications

Cat. No.: HY-13238

CAS No.: 1051375-16-6

Purity: 99.85%

Synonyms: S/GSK1349572

Target:

HIV Integrase HIV

Research Areas:

Infection

Dolutegravir (S/GSK1349572) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC₅₀ of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir (S/GSK1349572) inhibits HIV-1 viral replication with an IC₅₀ of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC₅₀=3.6-5.8 nM) .

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38

Dolutegravir sodium

38 Cited Publications

Cat. No.: HY-13238A

CAS No.: 1051375-19-9

Purity: 99.97%

Synonyms: S/GSK1349572 sodium

Target:

HIV Integrase HIV

Research Areas:

Infection

Dolutegravir sodium (S/GSK1349572 sodium) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC₅₀ of 2.7 nM for HIV-1 integrase-catalyzed strand transfer. Dolutegravir sodium (S/GSK1349572 sodium) inhibits HIV-1 viral replication with an IC₅₀ of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir sodium (S/GSK1349572 sodium) retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC₅₀=3.6-5.8 nM) .

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31

Proteinase K

31 Cited Publications

Cat. No.: HY-108717

CAS No.: 39450-01-6

Synonyms: Protease K

Target:

Ser/Thr Protease

Research Areas:

Others

Proteinase K (Protease K) is a nonspecific serine protease that is useful for general digestion of proteins. Proteinase K is active in the presence of SDS or urea and over a wide range of pH (4-12), salt concentrations, and temperatures. Proteinase K can be use for promoting methods of viral nucleic acid extraction, and detection .

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29

GS-441524

29 Cited Publications

Cat. No.: HY-103586

CAS No.: 1191237-69-0

Purity: 99.89%

Target:

DNA/RNA Synthesis SARS-CoV

Research Areas:

Infection

GS-441524 is a potent, orally active and CNS-penetrant viral RNA-dependent RNA polymerase inhibitor. GS-441524 competes with natural nucleosides to block viral RNA transcription as an alternative substrate and RNA chain terminator. GS-441524 inhibits the replication of feline infectious peritonitis virus, African swine fever virus, and severe acute respiratory syndrome coronavirus 2. GS-441524 reduces viral RNA levels in cats. GS-441524 can be used in research related to feline infectious peritonitis, African swine fever, and coronavirus disease 2019 (COVID-19) .

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29

GS-441524 hydrochloride

29 Cited Publications

Cat. No.: HY-103586A

CAS No.: 2378280-82-9

Target:

DNA/RNA Synthesis SARS-CoV

Research Areas:

Infection

GS-441524 hydrochloride is a potent, orally active and CNS-penetrant viral RNA-dependent RNA polymerase inhibitor. GS-441524 hydrochloride competes with natural nucleosides to block viral RNA transcription as an alternative substrate and RNA chain terminator. GS-441524 hydrochloride inhibits the replication of feline infectious peritonitis virus, African swine fever virus, and severe acute respiratory syndrome coronavirus 2. GS-441524 hydrochloride reduces viral RNA levels in cats. GS-441524 hydrochloride can be used in research related to feline infectious peritonitis, African swine fever, and coronavirus disease 2019 (COVID-19) .

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