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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
viral replication cycle
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "viral replication cycle" in MCE Product Catalog:
6
6 Publications Verification
Synonyms: PF-74
PF-3450074 (PF-74) is a specifical inhibitor of HIV-1 capsid protein (CA) and displays a broad-spectrum inhibition of HIV isolates with submicromolar potency (EC50=8-640 nM). PF-3450074 (PF-74) acts at an early stage of HIV-1 infection, inhibits viral replication by directly competing with the binding of CPSF6 and NUP153, and blocks the uncoating, assembly, and the reverse transcription steps of the viral life cycle . CPSF6: nuclear host factors cleavage and polyadenylation specific factor 6; NUP153: nucleoporin 153.
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9-Amino-6-chloro-2-methoxyacridine (ACMA) is an acridine derivative and Fluorescent probe. 9-Amino-6-chloro-2-methoxyacridine inhibits viral replication, inhibits DNA synthesis and protein metabolism through cell cycle arrest, and induces lipid metabolism regulation, genotoxicity, mutagenicity, and cytotoxicity through DNA strand breaks. 9-Amino-6-chloro-2-methoxyacridine partially intercalates into DNA, forming three distinct complexes, stabilizes the DNA helix, and quenches fluorescence upon intercalation through electron transfer with guanine. 9-Amino-6-chloro-2-methoxyacridine monitors the generation and collapse of the proton motive force, H + pumping by F1F0-ATP synthase, and the collapse of pH gradients in inverted membrane vesicles. 9-Amino-6-chloro-2-methoxyacridine shows potent anti-BVDV activity. 9-Amino-6-chloro-2-methoxyacridine can be used for research on bovine viral diarrhea virus infection, leishmaniasis, and MRSA infection .
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3 Cited Publications
Cat. No.: HY-N1401
CAS No.: 112246-15-8
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Carbinoxamine maleate salt is a blood-brain barrier-permeable histamine H1 receptor antagonist. Carbinoxamine maleate salt blocks the action of histamine on H1 receptors, reducing symptoms such as sneezing, rhinitis, rhinorrhea, erythema, pruritus and urticaria. Carbinoxamine maleate salt inhibits influenza virus entry into cells via endocytosis, targets the early stage of the viral life cycle, and simultaneously reduces viral replication levels in the lungs, alleviating pathological damage and inflammatory responses in lung tissues. Carbinoxamine maleate salt can be used in research on allergic rhinitis, influenza, etc.
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1 Cited Publications
Cat. No.: HY-N4183
CAS No.: 72357-31-4
Category:
Leguminosae/Fabaceae Extract Plant Flavonoids Flavones Glycyrrhiza uralensis Fisch. Extract Phenols Polyphenols Disease Research Fields Cancer
Target:
Cat. No.: HY-B0277A
CAS No.: 29984-33-6
Synonyms: ara-AMP; ara-A 5'-monophosphate
Research Areas:
Vidarabine phosphate (ara-AMP; ara-A 5'-monophosphate) is a purine nucleoside antiviral agent and a prodrug of Vidarabine (HY-B0277). Vidarabine phosphate is rapidly converted into the antiviral active Vidarabine in vivo, which selectively inhibits viral DNA polymerase and cellular ribonucleotide reductase, thereby blocking viral replication. Vidarabine phosphate also exhibits antifungal activity, induces late-stage cellular apoptosis, and causes cell cycle arrest. Vidarabine phosphate can be used in research related to severe chronic active Epstein-Barr virus (EBV) infection, herpes infection, and candidiasis .
Neuraminidase, arthrobacter ureafaciens is a neuraminidase derived from Arthrobacter ureafaciens. Neuraminidase, arthrobacter ureafaciens catalyzes the removal of sialic acid residues from cell surfaces and viral glycoconjugates. Neuraminidase, arthrobacter ureafaciens enhances HIV-1-mediated syncytium formation and promotes the viral binding and entry steps in the HIV-1 replication cycle .
Synonyms: NK01-63
Coronastat is a potent inhibitor of the SARS-CoV-2 3CL protease. The SARS-CoV-2 3CL protease is a critical agent target for small molecule COVID-19, given its likely agentgability and essentiality in the viral maturation and replication cycle .
Cat. No.: HY-121663
CAS No.: 400863-77-6
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ST-148 is a novel small molecule compound that has potent inhibitory effects against all four dengue virus serotypes. In the nonlethal AG129 mouse dengue virus infection model, ST-148 significantly reduced viremia and viral load in vital organs and tended to reduce plasma cytokine levels. Compound resistance was associated with the dengue virus capsid (C) gene, and the direct interaction of ST-148 with the C protein was presumed to be achieved through the protein's built-in fluorescence change in the presence of the compound. Therefore, ST-148 appears to interact with the dengue virus C protein and inhibit one or more unique steps of the viral replication cycle.
Cat. No.: HY-173338
CAS No.: 1438403-50-9
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MSRV-IN-1 (Compound M3) is an inhibitor targeting aquatic rhabdoviruses (such as MSRV, SVCV and IHNV). Its IC50 values for inhibiting MSRV, SVCV and IHNV are 0.92 μM, 2.92 μM and 2.78 μM respectively. MSRV-IN-1 does not act directly on the virions but rather inhibits viral replication by altering the cell cycle arrest state in the S phase induced by the virus and disrupting the viral replication environment. When administered intraperitoneally at a dose of 20 mg/kg, MSRV-IN-1 can significantly increase the survival rate of largemouth bass infected with MSRV by 35.98% and reduce the viral loads in the liver, spleen and kidney. MSRV-IN-1 can be used in the research of diseases related to rhabdoviruses in aquaculture .
Cat. No.: HY-P10509
CAS No.: 127902-44-7
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(±)-Carbinoxamine is a blood-brain barrier-permeable histamine H1 receptor antagonist. (±)-Carbinoxamine blocks the action of histamine on H1 receptors, reducing symptoms such as sneezing, rhinitis, rhinorrhea, erythema, pruritus and urticaria. (±)-Carbinoxamine inhibits influenza virus entry into cells via endocytosis, targets the early stage of the viral life cycle, and simultaneously reduces viral replication levels in the lungs, alleviating pathological damage and inflammatory responses in lung tissues. (±)-Carbinoxamine can be used in research on allergic rhinitis, influenza, etc.
Cat. No.: HY-B1589AS
CAS No.: 2747914-08-3
Cat. No.: HY-B0277AR
CAS No.: 29984-33-6
Synonyms: ara-AMP (Standard); ara-A 5'-monophosphate (Standard)
Target:
Reference Standards Apoptosis Drug Intermediate Fungal Reactive Oxygen Species (ROS) EBV HSV DNA/RNA Synthesis
Research Areas:
Vidarabine phosphate (ara-AMP; ara-A 5'-monophosphate) (Standard) is the analytical standard of Vidarabine phosphate. This product is intended for research and analytical applications. Vidarabine phosphate is a purine nucleoside antiviral agent and a prodrug of Vidarabine (HY-B0277). Vidarabine phosphate is rapidly converted into the antiviral active Vidarabine in vivo, which selectively inhibits viral DNA polymerase and cellular ribonucleotide reductase, thereby blocking viral replication. Vidarabine phosphate also exhibits antifungal activity, induces late-stage cellular apoptosis, and causes cell cycle arrest. Vidarabine phosphate can be used in research related to severe chronic active Epstein-Barr virus (EBV) infection, herpes infection, and candidiasis.
Cat. No.: HY-B1589AR
CAS No.: 3505-38-2
Research Areas:
Carbinoxamine maleate salt (Standard) is the analytical standard of Carbinoxamine maleate salt (HY-B1589A). This product is intended for research and analytical applications. Carbinoxamine maleate salt is a blood-brain barrier-permeable histamine H1 receptor antagonist. Carbinoxamine maleate salt blocks the action of histamine on H1 receptors, reducing symptoms such as sneezing, rhinitis, rhinorrhea, erythema, pruritus and urticaria. Carbinoxamine maleate salt inhibits influenza virus entry into cells via endocytosis, targets the early stage of the viral life cycle, and simultaneously reduces viral replication levels in the lungs, alleviating pathological damage and inflammatory responses in lung tissues. Carbinoxamine maleate salt can be used in research on allergic rhinitis, influenza, etc.
Cat. No.: HY-N1401R
CAS No.: 112246-15-8
Category:
Triterpenes Human Gut Microbiota Metabolites Plant Terpenoids Panax ginseng C. A. Meyer Extract Endogenous metabolite Araliaceae Extract
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Cat. No.: HY-183592
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Research Areas:
Anti-virus agent 2 is an orally active and selective anti-orthopoxvirus (poxvirus) agent, with EC50 values of 6.1 μM and 47.1 μM against VTT-Fluc and MPXV clade IIb, respectively. Anti-virus agent 2 covalently binds to viral A17L protein and mRNA methyltransferase, blocks viral membrane fusion and intracellular biosynthesis, and acts on multiple stages of the viral replication cycle. Anti-virus agent 2 achieves viral inhibition in nude mouse models. Anti-virus agent 2 can be used for the research of orthopoxvirus infections such as monkeypox and smallpox .
Cat. No.: HY-183185
CAS No.: 3028405-31-1
BZ-30 is an orally active broad-spectrum SARS-CoV-2 inhibitor. BZ-30 acts on the early stage of the viral life cycle, can partially inhibit the endosomal entry process and reduce viral replication levels. BZ-30 reduces viral load, improves pulmonary pathological conditions, and decreases the lung-to-body weight ratio in hamster models challenged with SARS-CoV-2. BZ-30 can be used for research related to COVID-19 .
Cat. No.: HY-180882
Synonyms: EIDD-3608
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Research Areas:
GHP-88310 is an orally active broad-spectrum paramyxovirus and orthomyxovirus inhibitor that targets the L protein-RdRP complex, and exhibits activity against respiratory viruses and viruses of the genus Morbillivirus . GHP-88310 binds to the central cavity of the polymerase protein, blocks replicase and transcriptase activities, interferes with the viral life cycle and inhibits viral replication . GHP-88310 can be used in studies of paramyxovirus infections, including morbillivirus-like diseases, human parainfluenza virus type 3 infection and measles .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
