93

93 Publications Verification

Synonyms: Calcein acetoxymethyl ester

Calcein AM, has cell membrane permeability and can easily enter the cell. Calcein AM has no fluorescence and is hydrolyzed by endogenous esterase in the cell to produce polar molecule Calcein (Calcein), which has strong negative charge and cannot permeate the cell membrane. Calcein can emit strong green fluorescence, so it is often used with Propidium Iodide for cell viability/virulence detection, excitation/emission wavelength: 494/515 nm .

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21

c-di-AMP disodium

21 Cited Publications

Cat. No.: HY-12326A

CAS No.: 2734909-87-4

Synonyms: Cyclic diadenylate disodium; Cyclic-di-AMP disodium

Category:

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

STING Bacterial Endogenous Metabolite

c-di-AMP (Cyclic diadenylate) sodium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP sodium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP sodium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .

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21

c-di-AMP diammonium

21 Cited Publications

Cat. No.: HY-12326B

Purity: 99.36%

Synonyms: Cyclic diadenylate diammonium; Cyclic-di-AMP diammonium

Category:

Natural Products Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

STING Bacterial Endogenous Metabolite

c-di-AMP diammonium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP diammonium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP diammonium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .

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16

Clindamycin hydrochloride monohydrate

16 Cited Publications

Cat. No.: HY-N7118

CAS No.: 58207-19-5

Target:

Bacterial Antibiotic

Research Areas:

Infection Cancer

Clindamycin hydrochloride monohydrate is an oral protein synthesis inhibitory agent that has the ability to suppress the expression of virulence factors in Staphylococcus aureus at sub-inhibitory concentrations (sub-MICs). Clindamycin hydrochloride monohydrate resistance results from enzymatic methylation of the antibiotic binding site in the 50S ribosomal subunit (23S rRNA). Clindamycin hydrochloride monohydrate decreases the production of Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1) or alpha-haemolysin (Hla) .

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16

Clindamycin

16 Cited Publications

Cat. No.: HY-B1455

CAS No.: 18323-44-9

Target:

Bacterial Antibiotic Parasite

Research Areas:

Infection Cancer

Clindamycin is an orally active and broad-spectrum bacteriostatic lincosamide antibiotic. Clindamycin can inhibit bacterial protein synthesis, possessing the ability to suppress the expression of virulence factors in Staphylococcus aureus at sub-inhibitory concentrations (sub-MICs). Clindamycin resistance results from enzymatic methylation of the antibiotic binding site in the 50S ribosomal subunit (23S rRNA). Clindamycin decreases the production of Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1) or alpha-haemolysin (Hla). Clindamycin also can be used for researching malaria .

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9

Cyclic-di-GMP disodium

9 Cited Publications

Cat. No.: HY-110382

CAS No.: 2222132-40-1

Purity: 98.78%

Synonyms: c-di-GMP disodium; cyclic diguanylate disodium; 5GP-5GP disodium

Category:

Natural Products Endogenous metabolite Disease Research Fields Cancer

Target:

STING Endogenous Metabolite

Cyclic-di-GMP disodium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP disodium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP disodium can be used in cancer research .

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9

Cyclic-di-GMP diammonium

9 Cited Publications

Cat. No.: HY-107780B

CAS No.: 609343-82-0

Purity: 99.07%

Synonyms: c-di-GMP diammonium; cyclic diguanylate diammonium; 5GP-5GP diammonium

Category:

Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields

Target:

STING Endogenous Metabolite

Cyclic-di-GMP diammonium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP diammonium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP diammonium can be used in cancer research .

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8

Cyclo(Phe-Pro)

8 Cited Publications

Cat. No.: HY-P1934

CAS No.: 14705-60-3

Synonyms: Cyclo(phenylalanylprolyl); A-64863

Target:

HCV Bacterial Antibiotic Reactive Oxygen Species (ROS)

Research Areas:

Infection

Cyclo(Phe-Pro) (Cyclo(phenylalanylprolyl)) is a quorum-sensing molecule of Vibrio vulnificus that specifically interacts with RIG-I, inhibiting RIG-I polyubiquitination, suppressing IRF-3 activation, and reducing type I interferon production. Cyclo(Phe-Pro) enhances susceptibility to HCV and influenza virus and also alleviates plant aluminum toxicity stress. The mechanism of Cyclo(Phe-Pro) involves the regulation of host immune signaling pathways, bacterial virulence gene expression, and plant antioxidant systems, making it a promising candidate for research in viral infections, bacterial virulence regulation, and agricultural stress resistance .

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7

Hinokiflavone

7 Cited Publications

Cat. No.: HY-N2360

CAS No.: 19202-36-9

Category:

Flavonoids Phenols Polyphenols Plants Disease Research Fields 500 - Internal Server Error | MedChemExpress

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