935

Erastin

935 Publications Verification

Cat. No.: HY-15763

CAS No.: 571203-78-6

Purity: 99.62%

Target:

VDAC Ferroptosis Disulfidptosis

Research Areas:

Cancer

Erastin is a ferroptosis inducer. Erastin exhibits the mechanism of ferroptosis induction related to ROS and iron-dependent signaling. Erastin inhibits voltage-dependent anion channels (VDAC2/VDAC3) and accelerates oxidation, leading to the accumulation of endogenous reactive oxygen species. Erastin also disrupts mitochondrial permeability transition pore (mPTP) with anti-tumor activity. Furthermore, Erastin can block the uptake of cystine mediated by SLC7A11 and also spares UMRC6-EV and -C91A cells from disulfidptosis under glucose starvation .

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29

Ebselen

29 Cited Publications

Cat. No.: HY-13750

CAS No.: 60940-34-3

Purity: 99.58%

Synonyms: SPI-1005; PZ-51; CCG-39161

Target:

Calcium Channel Virus Protease HIV Phosphatase

Research Areas:

Infection Neurological Disease Inflammation/Immunology Cancer

Ebselen (SPI-1005), a glutathione peroxidase mimetic, is a potent voltage-dependent calcium channel (VDCC) blocker . Ebselen potently inhibits M ^pro (IC₅₀=0.67 μM) and COVID-19 virus (EC₅₀=4.67 μM) .Ebselen is an inhibitor of HIV-1 capsid CTD dimerization. Ebselen, an organoselenium compound, can permeate the blood-brain barrier and has anti-inflammatory, antioxidant and anticancer activity .

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21

VBIT-4

21 Cited Publications

Cat. No.: HY-129122

CAS No.: 2086257-77-2

Purity: 99.46%

Target:

VDAC

Research Areas:

Cardiovascular Disease Neurological Disease

VBIT-4 is an inhibitor of voltage-dependent anion channel 1 (VDAC1) oligomerization with a binding affinity (K_d) of 17 μM. VBIT-4, as an apoptosis inhibitor, can be used for therapeutic purposes in apoptosis-associated disorders, such as neurodegenerative and cardiovascular diseases .

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17

Amlodipine

17 Cited Publications

Cat. No.: HY-B0317

CAS No.: 88150-42-9

Target:

Calcium Channel

Research Areas:

Cardiovascular Disease Cancer

Amlodipine, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine can be used for the research of high blood pressure and cancer .

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17

Amlodipine besylate

17 Cited Publications

Cat. No.: HY-B0317B

CAS No.: 111470-99-6

Synonyms: Amlodipine benzenesulfonate

Target:

Calcium Channel

Research Areas:

Cardiovascular Disease Cancer

Amlodipine besylate (Amlodipine benzenesulfonate), an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine besylate can be used for the research of high blood pressure and cancer .

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17

Amlodipine maleate

17 Cited Publications

Cat. No.: HY-B0317A

CAS No.: 88150-47-4

Target:

Calcium Channel

Research Areas:

Cardiovascular Disease Cancer

Amlodipine maleate is a dihydropyridine calcium channel blocker, acts as an orally active antianginal agent. Amlodipine maleate blocks the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine maleate can be used for the research of high blood pressure and cancer .

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12

DCPIB

12 Cited Publications

Cat. No.: HY-103371

CAS No.: 82749-70-0

Purity: 99.83%

Target:

Chloride Channel Potassium Channel

Research Areas:

Neurological Disease

DCPIB is a selective, reversible and potent inhibitor of volume-regulated anion channels (VRAC). DCPIB voltage-dependently activates potassium channels TREK1 and TRAAK, and inhibits TRESK, TASK1 and TASK3 (IC₅₀s: 0.14, 0.95, 50.72 μM, respectively). DCPIB is also a selective blocker of swelling-induced chloride current (I_Cl,swell), with an IC₅₀ of 4.1 μM. DCPIB is a useful tool for investigating structure-function studies of K2P channels .

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9

L-Phenylalanine

9 Cited Publications

Cat. No.: HY-N0215

CAS No.: 63-91-2

Synonyms: (S)-2-Amino-3-phenylpropionic acid

Category:

Microorganisms Animals Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields

Target:

Calcium Channel Endogenous Metabolite iGluR

L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca ⁺ channels antagonist with a K_i of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (K_B of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals .

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7

Triamterene

7 Cited Publications

Cat. No.: HY-B0575

CAS No.: 396-01-0

Target:

Sodium Channel G protein-coupled Bile Acid Receptor 1

Research Areas:

Cardiovascular Disease Neurological Disease Metabolic Disease Cancer

Triamterene blocks epithelial Na ⁺ channel (ENaC) in a voltage-dependent manner, which used as a mild diuretic. Triamterene is an inhibitor of the TGR5 receptor .

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7

Spironolactone

7 Cited Publications

Cat. No.: HY-B0561

CAS No.: 52-01-7

Synonyms: SC9420

Target:

Mineralocorticoid Receptor Androgen Receptor Autophagy Calcium Channel

Research Areas:

Cardiovascular Disease Metabolic Disease Endocrinology Cancer

Spironolactone is an aldosterone antagonist that acts on the aldosterone mineralocorticoid receptor (IC₅₀=24 nM) and androgen receptor (IC₅₀=77 nM), promotes podocyte autophagy and regulates pain. Spironolactone improves hypertension-related vascular hypertrophy and remodeling by reducing angiotensin II (Ang II)-induced inflammation, reduces aldosterone-induced vascular and soft tissue calcification through PIT1-dependent signaling, and alleviates vascular dysfunction in type II diabetic mice by reducing oxidative stress and restoring NO/GC signaling; at low concentrations, it and its metabolites can interfere with aldosterone biosynthesis in the adrenal cortex and inhibit voltage-dependent Ca ²⁺ channels to exert antihypertensive effects .

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