vomits | MedChemExpress (MCE) Life Science Reagents

Research Areas:

Ondansetron (GR 38032; SN 307) is a highly selective 5-HT₃ receptor antagonist with an IC₅₀ value of 103 pM. Ondansetron exerts its antiemetic effect by antagonizing 5-HT receptors located in localized neurons in the peripheral and central nervous systems. Ondansetron can inhibit nausea and vomiting induced by chemotherapy and radiotherapy .

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13

Ondansetron hydrochloride

13 Cited Publications

Cat. No.: HY-B0002

CAS No.: 99614-01-4

Synonyms: GR 38032 hydrochloride; SN 307 hydrochloride

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Research Areas:

Ondansetron (GR 38032; SN 307) hydrochloride is a highly selective 5-HT₃ receptor antagonist with an IC₅₀ value of 103 pM. Ondansetron hydrochloride exerts its antiemetic effect by antagonizing 5-HT receptors located in localized neurons in the peripheral and central nervous systems. Ondansetron hydrochloride can inhibit nausea and vomiting induced by chemotherapy and radiotherapy .

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13

Ondansetron hydrochloride dihydrate

13 Cited Publications

Cat. No.: HY-B0002A

CAS No.: 103639-04-9

Synonyms: GR 38032 hydrochloride dihydrate; SN 307 hydrochloride dihydrate

Target:

Research Areas:

Ondansetron (GR 38032; SN 307) hydrochloride dehydrate is a highly selective 5-HT₃ receptor antagonist with an IC₅₀ value of 103 pM. Ondansetron hydrochloride dehydrate exerts its antiemetic effect by antagonizing 5-HT receptors located in localized neurons in the peripheral and central nervous systems. Ondansetron hydrochloride dehydrate can inhibit nausea and vomiting induced by chemotherapy and radiotherapy .

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4

Netupitant

4 Cited Publications

Cat. No.: HY-16346

CAS No.: 290297-26-6

Synonyms: CID 6451149

Target:

Netupitant (CID 6451149) is a blood-brain barrier penetrable, orally active NK1 receptor inhibitor with a K_i of 0.95 nM (CHO cells) against the human receptor. Netupitant antagonizes the effects induced by Substance P, inhibits the maximal response of Substance P with a long-lasting action, and suppresses NK1 agonist-induced behaviors in mice and gerbils. Netupitant reduces the frequency of bladder contractions, prolongs contraction intervals, decreases basal pressure at high doses, and acts on the afferent branch of the micturition reflex. Netupitant can be used in research related to overactive bladder, chemotherapy-induced nausea and vomiting, post-operative nausea and vomiting, anxiety disorders, and depression .

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4

Fosaprepitant dimeglumine

4 Cited Publications

Cat. No.: HY-14407A

CAS No.: 265121-04-8

Purity: 98.02%

Synonyms: MK-0517; L785298

Target:

Neurological Disease Endocrinology Cancer

Research Areas:

Fosaprepitant dimeglumine (MK-0517) is a proagent of Aprepitant (HY-10052). Fosaprepitant dimeglumine is a neurokinin-1 receptor antagonist, which is development for the prevention of chemotherapy-induced nausea and vomiting (CINV) .

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3

Granisetron

3 Cited Publications

Cat. No.: HY-B0071

CAS No.: 109889-09-0

Synonyms: BRL 43694

Target:

Research Areas:

5-HT Receptor Dopamine Receptor

Granisetron (BRL 43694) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.

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3

Metoclopramide

3 Cited Publications

Cat. No.: HY-17382

CAS No.: 364-62-5

Target:

Research Areas:

Endocrinology

Metoclopramide is a potent antagonist of 5-HT₃ and dopamine D2 receptor, with IC₅₀s of 308 nM and 483 nM, respectively. Metoclopramide can be used for the research of nausea and vomiting, gastro-oesophageal reflux, and gastroparesis .

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3

Granisetron Hydrochloride

3 Cited Publications

Cat. No.: HY-B0071A

CAS No.: 107007-99-8

Synonyms: BRL 43694A

Target:

Neurological Disease Cancer

Research Areas:

Granisetron (Hydrochloride) (BRL 43694A) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.

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3

Metopimazine

3 Cited Publications

Cat. No.: HY-116578

CAS No.: 14008-44-7

Purity: 98.03%

Synonyms: EXP999; RP9965

Target:

Dopamine Receptor

Research Areas:

Metopimazine (EXP999; RP9965) is a phenothiazine, orally available, selective dopamine D2 receptor antagonist that does not penetrate the blood-brain barrier. Metopimazine blocks dopamine D2 receptors in the chemoreceptor trigger zone and the periphery, thereby inhibiting nausea and vomiting. Metopimazine is indicated for chemotherapy-induced nausea and vomiting, and has low central side effects due to its poor brain penetration. The use of metopimazine in acute gastroenteritis may have potential risks .

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3

Bromopride

3 Cited Publications

Cat. No.: HY-B1164

CAS No.: 4093-35-0

Target:

Dopamine Receptor

Research Areas:

5-HT Receptor Dopamine Receptor

Bromopride is a selective, irreversible, competitive, and orally effective dopamine D2 receptor antagonist. Bromopride can pass through the blood-brain barrier, inhibit the vomiting center, and enhance gastrointestinal motility, exerting antiemetic and gastrointestinal motility effects. Bromopride antagonizes dopamine-mediated vomiting reflexes and promotes gastrointestinal smooth muscle contraction, and has no adverse effects on abdominal wall healing in rats with postoperative abdominal infection. Bromopride can be used for the study of digestive system diseases (such as gastric hypomotility, nausea and vomiting) .

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3

Metoclopramide hydrochloride hydrate

3 Cited Publications

Cat. No.: HY-17382A

CAS No.: 54143-57-6

Target:

Research Areas:

Endocrinology

Metoclopramide hydrochloride hydrate is a potent antagonist of 5-HT₃ and dopamine D2 receptor, with IC₅₀s of 308 nM and 483 nM, respectively. Metoclopramide hydrochloride hydrate can be used for the research of nausea and vomiting, gastro-oesophageal reflux, and gastroparesis .

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2

Palonosetron hydrochloride

2 Cited Publications

Cat. No.: HY-A0021

CAS No.: 135729-62-3

Target:

5-HT Receptor Flavivirus

Research Areas:

Infection Cardiovascular Disease Neurological Disease

Palonosetron hydrochloride is a 5-HT3 antagonist primarily used to prevent acute, delayed, and overall chemotherapy-induced nausea and vomiting. In addition, Palonosetron hydrochloride exhibits moderate anti-flavivirus activity and potent anti-Zika virus activity in mammalian cells. Palonosetron hydrochloride also possesses antidepressant activity .

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2

Azasetron hydrochloride

2 Cited Publications

Cat. No.: HY-B0068

CAS No.: 123040-16-4

Synonyms: Y-25130 hydrochloride

Target:

Research Areas:

5-HT Receptor Dopamine Receptor Histamine Receptor Autophagy Enterovirus Calcium Channel

Azasetron (Y-25130) hydrochloride, a benzamide derivative, is a potent and selective 5-HT3 receptor antagonist. Azasetron is used in the study for Chemotherapy-induced nausea and vomiting (CINV) .

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1

Levomepromazine

1 Cited Publications

Cat. No.: HY-B1693

CAS No.: 60-99-1

Synonyms: Methotrimeprazine

Target:

Research Areas:

Infection Neurological Disease Inflammation/Immunology

Levomepromazine (Methotrimeprazine) is an orally active antipsychotic compound and Ca ²⁺ release inducer. Levomepromazine inhibits SERCA pump and induces an increase in cytoplasmic Ca ²⁺ levels. Levomepromazine has antagonistic effects on a variety of neurotransmitter receptors, including dopamine, cholinergic, serotonin, and histamine receptors. Levomepromazine can induce adaptive ER stress and autophagy. In addition, Levomepromazine has antiviral, anti-inflammatory, neuroprotective and analgesic, sedative and anti-injurious activities. Levomepromazine can be used in the study psychiatric disorders and relieving nausea and vomiting .

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1

Maropitant

1 Cited Publications

Cat. No.: HY-10053

CAS No.: 147116-67-4

Purity: 99.52%

Target:

Neurological Disease Endocrinology

Research Areas:

Maropitant is an orally active NK1 receptor antagonist. Maropitant prevents vomiting and inhibits ulcerative dermatitis .

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1

Maropitant citrate hydrate

1 Cited Publications

Cat. No.: HY-10053A

CAS No.: 359875-09-5

Target: