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Cat. No.: HY-100565A

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SGC2085 hydrochloride

Name: SGC2085 hydrochloride
Brand: MedChemExpress
SKU: HY-100565A
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1 Cited Publications

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Based on 1 publication(s) in Google Scholar

SGC2085 hydrochloride is a potent and selective inhibitor of coactivator associated arginine methyltransferase 1 (CARM1) with an IC₅₀ of 50 nM. SGC2085 hydrochloride also selectively inhibits PRMT6 with an IC₅₀ value of 5.2 μM, but not other PRMT proteins.

For research use only. We do not sell to patients.

CAS No.: 1821908-49-9
Formula: C₁₉H₂₅ClN₂O₂
Molecular Weight:348.87

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (248 KB)

SGC2085 hydrochloride Chemical Structure

CAS No.: 1821908-49-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Purity & Documentation
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Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

PRMT6

5.2 μM (IC₅₀)

All Histone Methyltransferase Isoforms :

In Vitro

SGC2085 hydrochloride (1 μM, 10 μM, 50 μM; 48 h) is fully selective for 21 human protein methyltransferases^[1].
SGC2085 hydrochloride (10 μM; 48 h) exhibits low cell permeability and no cell activity in HEK293 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1821908-49-9
Molecular Weight 348.87
Formula C₁₉H₂₅ClN₂O₂
SMILES

[H]Cl.CC1=CC(OC2=CC=C(CNC([C@@H](N)C)=O)C=C2C)=CC(C)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Acta Pharmacol Sin

P300/CBP inhibition sensitizes mantle cell lymphoma to PI3Kδ inhibitor idelalisib. [Abstract]

2022 Feb;43(2):457-469. PMID: 33850273

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (248 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

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Bioz

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SGC2085 hydrochloride

1 Cited Publications

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Purity & Documentation

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SGC2085 hydrochloride

Publications Citing Use of MedChemExpress (MCE) SGC2085 hydrochloride

All Histone Methyltransferase Isoforms