Sirt1/2-IN-6
Sirt1/2-IN-6 is a SIRT1/2 inhibitor with IC50 values of 5.3 μM and 2.2 μM, respectively. Sirt1/2-IN-6 induces a dose-dependent increase in acetylated α-Tubulin levels. Sirt1/2-IN-6 can be used for hepatocellular carcinoma research.
For research use only. We do not sell to patients.
- Formula: C20H21N5O2S
- Molecular Weight:395.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
SIRT1 5.3 μM (IC50) |
SIRT2 2.2 μM (IC50) |
In Vitro
Sirt1/2-IN-6 (10-40 μM; 36 h) increases acetylated α-tubulin levels in HepG2 cells in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2 cells
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Concentration:10, 20, 40 μM
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Incubation Time:36 h
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Result:Caused a dose-dependent increase in acetylated α-tubulin levels compared with control.
The blot showed 40, 20, and 10 μM lanes with increasing acetyl-tubulin signal relative to vehicle.
Chemical Information
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Molecular Weight 395.48
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Formula C20H21N5O2S
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SMILES
O=C(OCC)C(C(NC1=CC=CC=C1)=NN2C)=C2NC(NC3=CC=CC=C3)=S
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sirt1/2-IN-6 Related Classifications
HY-189956 Related Classifications
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