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Cat. No.: HY-188057

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Sirusertib

Sirusertib (WEE1A&Myt1-IN-1) is a dual Wee1A/Myt1 inhibitor, with an IC₅₀ of ≤10 nM against Wee1A and ≤20 nM against Myt1. Sirusertib is applicable for cancer-related research.

For research use only. We do not sell to patients.

CAS No.: 3066062-53-8
Formula: C₂₇H₂₉N₉O₂
Molecular Weight:511.58

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Sirusertib Chemical Structure

CAS No.: 3066062-53-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

Sirusertib (WEE1A&Myt1-IN-1) is a dual Wee1A/Myt1 inhibitor, with an IC₅₀ of ≤10 nM against Wee1A and ≤20 nM against Myt1. Sirusertib is applicable for cancer-related research^[1].

All Wee1 Isoforms :

PKMYT1

In Vitro

Sirusertib (Compound 109) inhibits Wee1A and Myt1 with IC₅₀ values of ≤10 nM and ≤20 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3066062-53-8
Molecular Weight 511.58
Formula C₂₇H₂₉N₉O₂
SMILES

O=C1C2=CN=C(NC3=CC(C=NN4C)=C4C=C3)N=C2N(N1CC=C)C5=NC(OC6CCN(CC6)C)=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hans Mattias JÖNSSON, et al. Pyrazolo-pyrimidinone compounds for use in methods of inhibiting wee1 a kinase. WO2024254490A1. WIPO (PCT). 2024-06-07.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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