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Cat. No.: HY-N1240

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Sissotrin

Name: Sissotrin
Brand: MedChemExpress
SKU: HY-N1240
Price: 145.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: Biochanin A 7-glucoside; Sissonin)

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Sissotrin (Biochanin A 7-glucoside; Sissonin) is an orally active isoflavone glycoside natural product found in Leguminosae plants, with weak antibacterial activity. Sissotrin exacerbates the increase in blood glucose after glucose loading. Sissotrin is used in studies related to glucose metabolism.

For research use only. We do not sell to patients.

Purity : 98.46%
CAS No.: 5928-26-7
Formula: C₂₂H₂₂O₁₀
Molecular Weight:446.40

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Sissotrin Chemical Structure

CAS No.: 5928-26-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All Endogenous Metabolite Isoforms :

In Vitro

Oxidative StressBacterial InfectionOthers

Oxidative Stress

Sissotrin (compound 1) (1-1000 μM; 10 min) fails to protect HUVEC against H₂O₂-induced oxidative damage ^[1].

Bacterial Infection

Sissotrin (compound 1) (500-3.906 μg/mL; 24 h) exhibits weak antibacterial activity against Shigella flexneri CPC (MIC = 250 μg/mL) and Shigella flexneri NR 518 (MIC = 500 μg/mL), but shows no activity against Staphylococcus aureus ATCC 43300, Methicillin-resistant (HY-121544) Staphylococcus aureus 33591, Escherichia coli ATCC 25922, and Staphylococcus aureus CPC^[3].

Others

Sissotrin is an isoflavone glucoside obtained via microbial glycosylation of Biochanin A (HY-14595)^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

HUVEC
Concentration:

1, 3, 10, 30, 100, 300, 1000 μM
Incubation Time:

10 min (pre-incubation)
4 h (H₂O₂ challenge)
Result:

Did not prevent cellular damage induced by H2O2.
Did not show toxicity to the cells at concentrations up to 1 mM.

In Vivo

Carbohydrate Metabolism

Sissotrin (50-100 mg/kg, p.o., administered 10 min before glucose load) impairs glucose tolerance and exacerbates post-load hyperglycemia in normal Wistar rats in the OGTT^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar (Male, 140-170 g)^[2]
Dosage:

50, 100 mg/kg
Administration:

p.o.; single administration 10 min prior to glucose load
Result:

Caused a significant rise in blood glucose levels at 15, 30 and 60 min after the glucose load.
At 30 min after the glucose load, blood glucose was 172 mg/dL for 100 mg/kg versus 144 mg/dL for control.
Produced 133 mg/dL at 50 mg/kg.
The hyperglycaemic effect observed at 100 mg/kg was abolished at the lower dose of 50 mg/kg.

Related Protocols :

Chemical Information

CAS No. 5928-26-7
Appearance Solid
Molecular Weight 446.40
Formula C₂₂H₂₂O₁₀
Color White to off-white
SMILES

O=C1C(C2=CC=C(OC)C=C2)=COC3=CC(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)=CC(O)=C13
Synonyms

Biochanin A 7-glucoside; Sissonin
Structure Classification
- Flavonoids
- Isoflavones
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Vitor RF, et al. Flavonoids of an extract of Pterospartum tridentatum showing endothelial protection against oxidative injury. Journal of ethnopharmacology. 2004 Aug;93(2-3):363-70.

[2]. Paulo A, et al. The opposing effects of the flavonoids isoquercitrin and sissotrin, isolated from Pterospartum tridentatum, on oral glucose tolerance in rats. Phytotherapy research : PTR. 2008 Apr;22(4):539-43.

[3]. Tsamo D L F, et al. Semisynthetic Derivatives of Sissotrin Isolated from Trifolium baccarinii (Fabaceae) and Evaluation of Their Antibacterial Activities. Advances in Biological Chemistry, 2024, 14: 27-39.

[4]. Sordon S, et al. Microbial Glycosylation of Daidzein, Genistein and Biochanin A: Two New Glucosides of Biochanin A. Molecules (Basel, Switzerland). 2017 Jan 03;22(1):81.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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Sissotrin

All Endogenous Metabolite Isoforms