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Cat. No.: HY-184739

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SMP-70067-L

SMP-70067-L (DL10) is a conjugate of a toxic molecule and a linker, in which the toxin moiety is Exatecan (HY-13631) and the linker moiety is SMP-93566-4-Leu-Cit-PAB-Glu (Ac) (HY-184740). SMP-70067-L can be used to synthesize the ADC SMP-70067-X.

For research use only. We do not sell to patients.

CAS No.: 3120799-14-3
Formula: C₆₇H₈₂FN₁₃O₁₉
Molecular Weight:1392.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SMP-70067-L Chemical Structure

CAS No.: 3120799-14-3

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

All Drug-Linker Conjugates for ADC Isoforms :

In Vitro

The drug-linker conjugates of antibody-drug conjugates (ADCs) consist of active cytotoxic drugs and appropriate linkers. After conjugation with monoclonal antibodies, these conjugates can be used to prepare ADCs, which are highly selective and cytotoxic targeted drugs against cancer cells.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3120799-14-3
Molecular Weight 1392.44
Formula C₆₇H₈₂FN₁₃O₁₉
SMILES

CC[C@]1(C(OCC2=C1C=C3C4=NC5=CC(F)=C(C6=C5C([C@H](CC6)NC(OCC7=CC=C(C=C7NC([C@@H](NC(C)=O)CCC(O)=O)=O)NC([C@@H](NC([C@H](C(C)C)NC(CN8CCOCCN(CCOCC8)C(CCN9C(C=CC9=O)=O)=O)=O)=O)CCCNC(N)=O)=O)=O)=C4CN3C2=O)C)=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Heng X, et al. An intrinsically hydrophilic linker enables a stable, high-DAR exatecan-based HER2 ADC with potent antitumor activity. European journal of medicinal chemistry. 2026 Oct 15;316:119054. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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