SPC-180002
SPC-180002 is a SIRT1/3 dual inhibitor, with IC50 values of 1.13 and 5.41 μM, respectively. SPC-180002 disturbs redox homeostasis via ROS generation, which leads to an increase in both p21 protein stability and mitochondrial dysfunction. SPC-180002 strongly inhibits cell cycle progression and cancer cell growth. SPC-180002 activates the Nrf2 signaling pathway.
For research use only. We do not sell to patients.
- CAS No.: 2170274-53-8
- Formula: C18H23NO4
- Molecular Weight:317.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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HY-B0150
NicotinamideSIRT Inhibitor -
HY-B0150R
Nicotinamide (Standard) -
HY-13515
SirtinolSirtuin Inhibitor -
HY-100591
SirReal2Sirt2 Inhibitor -
HY-100732
CambinolSIRT1/2 Inhibitor -
HY-101278
ThiomyristoylSIRT2 Inhibitor -
HY-100591R
SirReal2 (Standard)Sirt2 Inhibitor -
HY-123194
SIRT2/6-IN-1SIRT6/SIRT2 Inhibitor -
HY-B0150G
Nicotinamide (GMP)SIRT Inhibitor -
HY-13515R
Sirtinol (Standard)Sirtuin Inhibitor -
HY-100732R
Cambinol (Standard)SIRT1/2 Inhibitor -
HY-101278R
Thiomyristoyl (Standard)SIRT2 Inhibitor
Biological Activity
Description
IC50 & Target
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SIRT1 1.13 ± 0.3 μM (IC50) |
SIRT3 5.41 ± 4.8 μM (IC50) |
In Vitro
SPC-180002 (0-5 μM, 24 h) inhibits cell cycle progression via p21 accumulation, which causes subsequent cellular senescence[1].
SPC-180002 dose not induce apoptosis and autophagy[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Five weeks female athymic nude mice (BALB/c)[1]
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Dosage:1 mg/kg or 5 mg/kg
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Administration:i.p., twice a week
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Result:Significantly impeded tumor progression. The gain of tumor volume in SPC-180002-treated mice was significantly reduced by 48% at the low dose (1 mg/kg) and by 52% at the high dose (5 mg/kg), compared to vehicle-treated mice.
- Flow cytometric DNA-content cell-cycle staining
- ROS/oxidative-stress fluorescent staining
- BrdU Incorporation Assay
- Protocol for Cell Counting and Cell Density Analysis
- Somatic Cell Culture
- Mitochondrial membrane-potential and mitochondrial mass staining
- Protocol for Cell Cycle
- CCK-8/WST-8 Cell Proliferation Assay
- Cell Counting-Based Growth Curve Assay
- MTT Cell Proliferation Assay
- Cell Viability Determination by MTT Colorimetric Assay
Chemical Information
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CAS No. 2170274-53-8
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Molecular Weight 317.38
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Formula C18H23NO4
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SMILES
O=C(C(CN(CCC1=CC=CC=C1)CC(C(OC)=O)=C)=C)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SPC-180002 Related Classifications
HY-155784 Related Classifications
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