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Cat. No.: HY-184379

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SRI-37264

SRI-37264 is a HIV-1 Nef inhibitor with a K_d value of 162 nM. SRI-37264 binds directly to HIV-1 Nef, disrupts the Nef·MHC-I·AP-1 μ1 complex, and inhibits the Nef-dependent enhancement of HIV-1 infectivity. SRI-37264 restores MHC-I expression on the surface of HIV-infected primary cells. SRI-37264 inhibits HIV-1 replication in primary macrophages. SRI-37264 is applicable to research related to HIV-1 infection.

For research use only. We do not sell to patients.

CAS No.: 2358714-71-1
Formula: C₁₇H₁₄ClN₃O₃S
Molecular Weight:375.83

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SRI-37264 Chemical Structure

CAS No.: 2358714-71-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Parmacokinetics
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All HIV Isoforms :

In Vitro

Viral InfectionAdaptive ImmunityOthers

Viral Infection

SRI-37264 (3-48 h) inhibits Nef-dependent HIV-1 infectivity in TZM-bl cells with an IC₅₀ of 0.32 μM and has no detectable cytotoxicity (CC₅₀ > 100 μM)^[1].

Adaptive Immunity

Viral Infection

SRI-37264 (1.0 μM; 24 h) partially restores cell-surface MHC-I expression by 15.9% in HIV-1-infected primary HLA-A2⁺ CD8-depleted PBMCs^[1].

Others

SRI-37264 (125 μM; 25 min) at a 5-fold molar excess disrupts preformed recombinant Nef-CD·AP-1 μ1 complexes in solution^[1].

Others

SRI-37264 has excellent metabolic stability with a half-life > 2 h in mouse and human liver microsomes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Parmacokinetics

Species	Dose	Route	T_1/2
Mice^[1]	1 mg/kg	i.v.	40 min

Chemical Information

CAS No. 2358714-71-1
Molecular Weight 375.83
Formula C₁₇H₁₄ClN₃O₃S
SMILES

O=C1C2=CC=CN=C2SN1C3=CC=C(C(C(N4CCOCC4)=O)=C3)Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Emert-Sedlak LA, et al. Inhibitors of HIV-1 Nef-Mediated Activation of the Myeloid Src-Family Kinase Hck Block HIV-1 Replication in Macrophages and Disrupt MHC-I Downregulation. ACS infectious diseases. 2022 Jan 14;8(1):91-105. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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