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Cat. No.: HY-15599A

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SSR128129E free acid

Name: SSR128129E free acid
Brand: MedChemExpress
SKU: HY-15599A
Availability: PreOrder

(Synonyms: SSR free acid)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

SSR128129E free acid is an orally available and allosteric FGFR inhibitor with an IC₅₀ of 1.9 μM for FGFR1.

For research use only. We do not sell to patients.

CAS No.: 848463-13-8
Formula: C₁₈H₁₆N₂O₄
Molecular Weight:324.33

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

SSR128129E free acid Chemical Structure

CAS No.: 848463-13-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Purity & Documentation
References
Calculators
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Biological Activity

Description

SSR128129E free acid is an orally available and allosteric FGFR inhibitor with an IC₅₀ of 1.9 μM for FGFR1.

IC₅₀ & Target

^[1]

FGFR1

1.9 μM (IC₅₀)

FGFR2

FGFR3

FGFR4

In Vitro

SSR128129E inhibits FGF2-induced EC proliferation with an IC₅₀ of 31±1.6 nM, migration with an IC₅₀ of 15.2±4.5 nM, and lamellipodia formation in a dose dependent manner. SSR128129E inhibits responses mediated by FGFR1-4. For instance, SSR128129E blocks EC migration in response to FGF1, a ligand of FGFR1 and FGFR4, and capillary tube formation in response to FGF19, a ligand of FGFR4. Proliferation and migration of the murine pancreatic Panc02 tumor cell line in response to FGF7 are also blocked by SSR128129E, showing that SSR128129E inhibits FGFR subtypes of other species as well. SSR128129E blocks different FGFR subtypes in various cell lines with nanomolar potency^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Oral delivery of SSR128129E (30 mg/kg/day, from day 3) inhibits growth of orthotopic Panc02 tumors by 44% and delays growth of Lewis lung carcinoma. oral SSR128129E (30 mg/kg/day, from day 5) reduces tumor size and weight by 53% and 40%, respectively. SSR128129E inhibits the growth of subcutaneous CT26 colon tumors by 34% and of the multidrug resistant MCF7/ADR breast cancer xenograft model by 40%. SSR128129E reduces tumor invasiveness and metastasis of Panc02 tumor cells to peritoneal lymph nodes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 848463-13-8
Molecular Weight 324.33
Formula C₁₈H₁₆N₂O₄
SMILES

COC1=C2N(C(C(C3=CC=C(N)C(C(O)=O)=C3)=O)=C1C)C=CC=C2
Synonyms

SSR free acid
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Journal Impact Factor

Cancer Cell

Senescence Reprogramming by TIMP1 Deficiency Promotes Prostate Cancer Metastasis. [Abstract]

2021 Jan 11;39(1):68-82.e9. PMID: 33186519

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bono F, et al. Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties. Cancer Cell. 2013 Apr 15;23(4):477-88. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

SSR128129E free acid

1 Cited Publications

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Purity & Documentation
References

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SSR128129E free acid

Publications Citing Use of MedChemExpress (MCE) SSR128129E free acid