Tafamidis-d3
Based on 1 Customer Validation
Tafamidis-d3 is deuterium labeled Tafamidis. Tafamidis is a potent and selective transthyretin (TTR) stabilizer, shows comparable potency and efficacy to the mutumant homotetramers V30M-TTR, V122I-TTR and wild type WT-TTR, with EC50s of 2.7-3.2 μM. Tafamidis inhibits amyloidogenesis.
For research use only. We do not sell to patients.
- Purity : 99.39%
- Formula: C14H4D3Cl2NO3
- Molecular Weight:311.13
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled CAS 594839-88-0
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Appearance Solid
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Molecular Weight 311.13
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Formula C14H4D3Cl2NO3
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SMILES
O=C(C1=C([2H])C([2H])=C2N=C(C3=CC(Cl)=CC(Cl)=C3)OC2=C1[2H])O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 37.5 mg/mL (120.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Bulawa, C.E., et al., Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade. Proc Natl Acad Sci U S A, 2012. 109(24): p. 9629-34. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2141 mL | 16.0705 mL | 32.1409 mL | 80.3523 mL |
| 5 mM | 0.6428 mL | 3.2141 mL | 6.4282 mL | 16.0705 mL | |
| 10 mM | 0.3214 mL | 1.6070 mL | 3.2141 mL | 8.0352 mL | |
| 15 mM | 0.2143 mL | 1.0714 mL | 2.1427 mL | 5.3568 mL | |
| 20 mM | 0.1607 mL | 0.8035 mL | 1.6070 mL | 4.0176 mL | |
| 25 mM | 0.1286 mL | 0.6428 mL | 1.2856 mL | 3.2141 mL | |
| 30 mM | 0.1071 mL | 0.5357 mL | 1.0714 mL | 2.6784 mL | |
| 40 mM | 0.0804 mL | 0.4018 mL | 0.8035 mL | 2.0088 mL | |
| 50 mM | 0.0643 mL | 0.3214 mL | 0.6428 mL | 1.6070 mL | |
| 60 mM | 0.0536 mL | 0.2678 mL | 0.5357 mL | 1.3392 mL | |
| 80 mM | 0.0402 mL | 0.2009 mL | 0.4018 mL | 1.0044 mL | |
| 100 mM | 0.0321 mL | 0.1607 mL | 0.3214 mL | 0.8035 mL |
Tafamidis-d3 Related Classifications
HY-14852S Related Classifications
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