Tafluprost acid (Standard)
Tafluprost acid (Standard) is the analytical standard of Tafluprost acid (HY-B0601). This product is intended for research and analytical applications. Tafluprost acid (AFP-172), an active metabolic form of Tafluprost, is a selective prostanoid FP receptor agonist. Tafluprost acid shows a high affinity for human prostanoid FP receptor with Ki and EC50 values of 0.4 nM and 0.53 nM, respectively. Tafluprost acid has 126 times weaker binding affinity for prostanoid EP3 receptor (IC50=67 nM) than for the prostanoid FP receptor. Tafluprost acid can be used in the research of glaucoma.
For research use only. We do not sell to patients.
- CAS No.: 209860-88-8
- Formula: C22H28F2O5
- Molecular Weight:410.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Purity & Documentation
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Help & FAQs
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HY-B0601
Tafluprost acidFP Receptor Agonist -
HY-B0600
TafluprostProstaglandin Receptor Agonist -
HY-108560
(+)-FluprostenolPTGER2 Agonist -
HY-B0577
LatanoprostProstaglandin Receptor Agonist -
HY-B0600R
Tafluprost (Standard)Prostaglandin Receptor Agonist -
HY-125774
Bimatoprost acidProstaglandin FP Receptor Agonist -
HY-113756A
Latanoprost acidFP Agonist -
HY-B0191
BimatoprostProstaglandin Analog -
HY-113481
Prostaglandin E3Prostaglandin Analog -
HY-I0021
BepotastineHistamine H1 Receptor Antagonist -
HY-100806S
Kynurenic acid-d5Stable Isotope -
HY-127143
Sterculic acidSCD1 Inhibitor
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 209860-88-8
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Molecular Weight 410.45
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Formula C22H28F2O5
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SMILES
O[C@H]([C@@H]1C/C=C\CCCC(O)=O)C[C@H]([C@@H]1/C=C/C(F)(COC2=CC=CC=C2)F)O
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Synonyms
AFP-172 (Standard)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Takagi Y, et al. Pharmacological characteristics of AFP-168 (tafluprost), a new prostanoid FP receptor agonist, as an ocular hypotensive drug. Exp Eye Res. 2004 Apr;78(4):767-76. [Content Brief]
[2]. Taketani Y, et al. Activation of the prostanoid FP receptor inhibits adipogenesis leading to deepening of the upper eyelid sulcus in prostaglandin-associated periorbitopathy. Invest Ophthalmol Vis Sci. 2014 Mar 4;55(3):1269-76. [Content Brief]
[3]. Fuwa M, et al. Advantages of Efficacy and Safety of Fixed-Dose Tafluprost/Timolol Combination Over Fixed-Dose Latanoprost/Timolol Combination. PLoS One. 2016 Jul 6;11(7):e0158797. [Content Brief]
[4]. Roh YJ, et al. Effects of AFP-172 on COX-2-induced angiogenic activities on human umbilical vein endothelial cells. Graefes Arch Clin Exp Ophthalmol. 2012 Dec;250(12):1765-75. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tafluprost acid (Standard) Related Classifications
HY-B0601R Related Classifications
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