Tagmokitug (FUT8-KO)
Tagmokitug (FUT8-KO) is the afucosylated version of Tagmokitug (HY-P991061) produced in FUT8-knockout cells. Tagmokitug (CHS-114; SRF-114) is a fully human IgG1 antibody targeting CCR8. Tagmokitug selectively binds to human CCR8 (Kd = 502 pM) and mediates the death of CCR8-expressing cells via antibody-dependent cellular cytotoxicity and antibody-dependent cellular phagocytosis. Tagmokitug selectively eliminates intratumoral regulatory T cells, induces tumor growth inhibition, remodels the tumor immune microenvironment, and promotes the differentiation of cytotoxic CD8+ T cell subsets. Tagmokitug can be used for the research of solid tumors.
For research use only. We do not sell to patients.
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Isotype
Human IgG1 lambda2
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
[1]|
CCR8 502 pM (Kd) |
In Vitro
Tagmokitug (4 h) potently induces NK cell-mediated ADCC against Raji-huCCR8 cells, with an EC50 of 2 ng/mL[1].
Tagmokitug (3 h) potently induces macrophage-mediated antibody-dependent cellular phagocytosis (ADCP) against Raji-huCCR8 cells, with an EC50 of 13.5 ng/mL[1].
Tagmokitug (overnight treatment) selectively eliminates intratumoral regulatory T cells (Tregs) in co-culture systems of activated NK cells with dissociated tumor cells from primary renal cell carcinoma (RCC) and colorectal cancer (CRC), while preserving conventional CD4+ and CD8+ T cells, and activates NK cells and monocytes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
- Gene Editing
- Phagocytosis Functional Assay
- Cell Cytotoxicity Assay
- Mammalian live/dead viability and cytotoxicity staining
- Patient-Derived Xenograft (PDX)
- Patient-Derived Orthotopic Xenograft (PDOX)
- Subcutaneous Cell-Line-Derived Xenograft
- Orthotopic Cell-Line Xenograft
- Research Protocol for Cancer Immunology
- Cell Viability Determination by MTT Colorimetric Assay
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Application
ELISA, FACS, Functional assay
Chemical Information
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SMILES
[Tagmokitug (FUT8-KO)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tagmokitug (FUT8-KO) Related Classifications
HY-P991061A Related Classifications
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