Tamoxifen-13C6
Tamoxifen-13C6 (ICI 47699-13C6) is the 13C-labeled Tamoxifen (HY-13757A). Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively. Tamoxifen activates autophagy and induces apoptosis. Tamoxifen also can induce gene knockout of CreER transgenic mouse.
For research use only. We do not sell to patients.
- CAS No.: 1346606-38-9
- Formula: C2013C6H29NO
- Molecular Weight:377.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
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Help & FAQs
Biological Activity
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
- Inducible CreER/Temporally Controlled Knockout Model
- Annexin V plus membrane-impermeant dye apoptosis staining
- Constitutive Germline Knockout Model
- Gene Editing
- CRISPR-Cas9 knockout in cultured mammalian cells
- Detection of Apoptosis
- TUNEL staining for apoptotic DNA fragmentation
- CRISPR-Cas9 zebrafish embryo editing
- Research Protocol for Endocrine Diseases
- Autophagy
- Apoptosis Solutions
- Lysosome and acidic-vesicle live-cell staining
- CRISPR/Cas9 Knockout Animal Model
- Macroautophagy Solutions
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1346606-38-9
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Unlabeled CAS 10540-29-1
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Molecular Weight 377.47
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Formula C2013C6H29NO
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SMILES
[H][13C]1=[13CH][13CH]=[13C](/C(C2=CC=C(C=C2)OCCN(C)C)=C(CC)/C3=CC=CC=C3)[13CH]=[13CH]1
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Synonyms
ICI 47699-13C6; (Z)-Tamoxifen-13C6; trans-Tamoxifen-13C6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tamoxifen-13C6 Related Classifications
HY-W778408 Related Classifications
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