Tefluthrin
Based on 1 Customer Validation
Tefluthrin is a pyrethroid insecticide. Tefluthrin prolongs the opening time of Nav1.6 sodium channels, leading to membrane depolarization and conductance block in the insect nervous system, thereby disrupting neural function.
For research use only. We do not sell to patients.
- Purity : 98.12%
- CAS No.: 79538-32-2
- Formula: C17H14ClF7O2
- Molecular Weight:418.73
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Storage:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
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Chemical Information
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CAS No. 79538-32-2
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Appearance Liquid to low melt solid
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Molecular Weight 418.73
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Formula C17H14ClF7O2
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Color Off-white to gray
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SMILES
O=C(OCC1=C(C(F)=C(C(F)=C1F)C)F)[C@@H]2C(C)([C@@H]2/C=C(C(F)(F)F)\Cl)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (238.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.97 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (5.97 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (565 KB)
- English - EN (565 KB)
- Français - FR (565 KB)
- Deutsch - DE (565 KB)
- Norwegian - NO (565 KB)
- Español - ES (565 KB)
- Swedish - SV (565 KB)
- Italian - IT (565 KB)
- Korean - KR (565 KB)
- Portuguese - PT (565 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.3882 mL | 11.9409 mL | 23.8817 mL | 59.7043 mL |
| 5 mM | 0.4776 mL | 2.3882 mL | 4.7763 mL | 11.9409 mL | |
| 10 mM | 0.2388 mL | 1.1941 mL | 2.3882 mL | 5.9704 mL | |
| 15 mM | 0.1592 mL | 0.7961 mL | 1.5921 mL | 3.9803 mL | |
| 20 mM | 0.1194 mL | 0.5970 mL | 1.1941 mL | 2.9852 mL | |
| 25 mM | 0.0955 mL | 0.4776 mL | 0.9553 mL | 2.3882 mL | |
| 30 mM | 0.0796 mL | 0.3980 mL | 0.7961 mL | 1.9901 mL | |
| 40 mM | 0.0597 mL | 0.2985 mL | 0.5970 mL | 1.4926 mL | |
| 50 mM | 0.0478 mL | 0.2388 mL | 0.4776 mL | 1.1941 mL | |
| 60 mM | 0.0398 mL | 0.1990 mL | 0.3980 mL | 0.9951 mL | |
| 80 mM | 0.0299 mL | 0.1493 mL | 0.2985 mL | 0.7463 mL | |
| 100 mM | 0.0239 mL | 0.1194 mL | 0.2388 mL | 0.5970 mL |
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