TG-2-IN-6
TG-2-IN-6 is a non-peptidic transglutaminase 2 (TG2) transamidase inhibitor with a human TG2 IC50 value of 7.64 μM. TG-2-IN-6 selectively induces apoptosis in breast cancer and triple-negative breast cancer cells. TG-2-IN-6 can be used in breast cancer-related research.
For research use only. We do not sell to patients.
- CAS No.: 1100223-22-0
- Formula: C18H15N3S2
- Molecular Weight:337.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Help & FAQs
Biological Activity
Description
In Vitro
TG-2-IN-6 (25-75 µM; 24 h) reduces the number of viable MDA-MB-231 cells, but does not significantly decrease the viability of HEK293 cells under the same conditions[1].
TG-2-IN-6 (0.78-100 µM) inhibits the transamidase activity of purified recombinant human TG2 with an IC50 of 7.64 µM and a Hill slope of -1.3[1].
TG-2-IN-6 inhibits purified human TG2 in the DMC-DC assay with an IC50 of 482 µM and an estimated Ki of 44 µM assuming competitive inhibition relative to DMC[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7, MDA-MB-436, and MDA-MB-231 human breast cancer cell lines
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Concentration:50 µM
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Incubation Time:48 h
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Result:Induced apoptosis in MCF-7, MDA-MB-436, and MDA-MB-231 breast cancer cells, with the strongest measured response in MDA-MB-231 cells.
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Cell Line:MDA-MB-231 and HEK293 cells
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Concentration:25, 50, 75 µM
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Incubation Time:24 h
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Result:Reduced viable-cell numbers in MDA-MB-231 cells but does not significantly reduce viability of HEK293 cells under the same conditions.
Chemical Information
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CAS No. 1100223-22-0
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Molecular Weight 337.46
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Formula C18H15N3S2
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SMILES
C1(CC2=CC=CC=C2)=NC(CSC3=NC=C4C=CC=CN43)=CS1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TG-2-IN-6 Related Classifications
HY-189952 Related Classifications
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