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Cat. No.: HY-187715

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Theophylline-triazole-estrone

Theophylline-triazole-estrone is an α-glucosidase inhibitor with an IC₅₀ of 123.9 μM. Theophylline-triazole-estrone interacts with the catalytic site of α-glucosidase and binds to the anti-apoptotic protein BCL-2. Theophylline-triazole-estrone reduces cancer cell viability and can be used in research related to type 2 diabetes and breast cancer.

For research use only. We do not sell to patients.

Formula: C₃₁H₃₉N₇O₄
Molecular Weight:573.69

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Theophylline-triazole-estrone Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

IC₅₀ & Target

^[1]

α‑glucosidase

123.9 μM (IC₅₀)

In Vitro

Carbohydrate MetabolismAnti-cancerOthers

Carbohydrate Metabolism

Theophylline-triazole-estrone (compound 4) (15.6-250 μM; 15 min) inhibits α-glucosidase, with an IC₅₀ of 123.9 μM and an inhibition rate of 84.4% at a concentration of 250 μM^[1].

Anti-cancer

Theophylline-triazole-estrone (7.8-250 μM; 48 h) reduces the viability of MCF-7 cells by 21%^[1].

Others

Theophylline-triazole-estrone binds to α-glucosidase via specific residue interactions with a binding energy of -10.8 kcal/mol; it also binds to BCL-2 isoform 1 with a binding energy of -8.3 kcal/mol^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

MCF-7 human breast adenocarcinoma cells
Concentration:

7.8, 15.6, 31.2, 62.5, 125, 250 μM
Incubation Time:

48 h
Result:

Showed a concentration-dependent antiproliferative trend.
Reduced average cell viability by 21% at 250 μM.

Related Protocols :

Chemical Information

Molecular Weight 573.69
Formula C₃₁H₃₉N₇O₄
SMILES

CN(C1=O)C(C2=C(N(C=N2)CCCN3N=NC(COC(C=C4)=CC(CC[C@@]5([H])[C@]6([H])CC7)=C4[C@@]5([H])CC[C@]6(C)C7=O)C3)N1C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Martinez D, et al. Novel Triazole-Linked Xanthine-Steroid Hybrids: Molecular Docking and In Vitro Evaluation Against α-Glucosidase and MCF-7 Cells. Chemistry & biodiversity. 2026 Jul;23(7):e71531.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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