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Cat. No.: HY-P2759

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Thioredoxin reductase

Name: Thioredoxin reductase
Brand: MedChemExpress
SKU: HY-P2759
Price: 675.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: TrxR)

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Thioredoxin reductase (TrxR) is a selenocysteine-containing NADPH-dependent disulfide oxidoreductase derived from rat liver that utilizes NADPH to reduce oxidized thioredoxin. Thioredoxin reductase can utilize the reducing capacity of human erythrocytes to study the uptake and reduction of α-Lipoic Acid (HY-N0492), and can also be used to investigate the activation mechanism of transglutaminase 2 (TG2) in the extracellular matrix using thioredoxin.

For research use only. We do not sell to patients.

CAS No.: 9074-14-0

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Thioredoxin reductase Chemical Structure

CAS No.: 9074-14-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All TrxR Isoforms :

TrxR1
TrxR2

All NADPH Oxidase Isoforms :

In Vitro

Anti-cancerOthers

Anti-cancer

Thioredoxin reductase (TrxR) is rapidly inactivated in serum by NADPH or NADPH-regenerating systems, and in the serum of H22 hepatoma-bearing mice, endogenous electrophilic compounds PpIX and 4-HNE are increased^[1].

Others

Thioredoxin reductase (from rat liver) can utilize the reducing capacity of human erythrocytes to study the uptake and reduction of α-lipoic acid^[2].
Thioredoxin reductase (from rat liver) is used to study the activation mechanism of transglutaminase 2 (TG2) in the extracellular matrix using thioredoxin^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-cancer

Thioredoxin reductase (TrxR) activity in serum from mice bearing H22 hepatocellular carcinoma‑xenografted tumours is elevated, reaching a plateau of approximately 15 nM, and is not correlated with tumour progression or ALT levels^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 9074-14-0
Appearance Liquid
Color Colorless to light yellow
SMILES

[Thioredoxin reductase]
Synonyms

TrxR
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhang L, et al. Serum thioredoxin reductase is highly increased in mice with hepatocellular carcinoma and its activity is restrained by several mechanisms. Free radical biology & medicine. 2016 Oct;99:426-435.

[2]. May JM, et al. Uptake and reduction of alpha-lipoic acid by human erythrocytes. Clin Biochem. 2007 Oct;40(15):1135-42.

[3]. Jin X, et al. Activation of extracellular transglutaminase 2 by thioredoxin. J Biol Chem. 2011 Oct 28;286(43):37866-73.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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Thioredoxin reductase

All TrxR Isoforms

All NADPH Oxidase Isoforms