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Cat. No.: HY-W207687

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Thymidine phosphorylase-IN-1

Thymidine phosphorylase-IN-1 (compound C17) is a potent Thymidine phosphorylase inhibitor with an IC₅₀ of 3.24 μM. Thymidine phosphorylase-IN-1 exhibits high binding affinity for Urease and Xanthine oxidase, with K_d values of 0.02 and 0.15 μM, respectively. Thymidine phosphorylase-IN-1 achieves optimal geometric complementarity and stable binding with the catalytic site of the target enzyme through hydrogen bonding, hydrophobic interactions, and π-π stacking mediated by the aminophenyl nitrogen atom. Thymidine phosphorylase-IN-1 can be used for research on tuberculosis.

For research use only. We do not sell to patients.

CAS No.: 4506-62-1
Formula: C₁₄H₁₀N₂O₂
Molecular Weight:238.24

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Thymidine phosphorylase-IN-1 Chemical Structure

CAS No.: 4506-62-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

Thymidine phosphorylase-IN-1 (compound C17) (0.156-5 mM; 5-50 min) inhibits Thymidine phosphorylase from E. coli (IC₅₀ = 3.24 μM), Urease from Jack bean (IC₅₀ = 36.83 μM), and bovine milk Xanthine oxidase (IC₅₀ = 10.40 μM)^[1].
Thymidine phosphorylase-IN-1 (1-8 µM; 3-10 min) exhibits concentration-dependent binding and forms stable enzyme-ligand complexes with Thymidine phosphorylase from E. coli (K_d = 0.32 μM), Urease from Jack bean (K_d = 0.02 μM), and bovine milk Xanthine oxidase (K_d = 0.15 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 4506-62-1
Molecular Weight 238.24
Formula C₁₄H₁₀N₂O₂
SMILES

C1=CC=C2C(=C1)C(=O)N(C3=CC=CC=C3N)C2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Khushal A, et al. Synthesis, multi-target enzyme inhibition, and in silico evaluation of phthalimide derivatives with relevance to tuberculosis-associated pathophysiology. Bioorganic chemistry. 2026 Aug 31;182:110441.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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