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Cat. No.: HY-188010

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TLR8 agonist 11

TLR8 agonist 11 is a selective human Toll-like receptor 8 (TLR8) agonist. TLR8 agonist 11 activates the hTLR8-dependent NF-κB signaling pathway. TLR8 agonist 11 can be used for the research of inflammation and immune-related diseases.

For research use only. We do not sell to patients.

CAS No.: 1449680-12-9
Formula: C₁₆H₁₈N₂O
Molecular Weight:254.33

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Please store the product under the recommended conditions in the Certificate of Analysis.

TLR8 agonist 11 Chemical Structure

CAS No.: 1449680-12-9

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Description

IC₅₀ & Target

^[1]

hTLR8

NF-κB

All Toll-like Receptor (TLR) Isoforms :

All NF-κB Isoforms :

In Vitro

Innate Immunity

TLR8 agonist 11 (compound 8e) is a human TLR8-specific agonist. It exhibits lower potency than its C2-butyl analog (compound 8d) and shows biphasic NF-κB induction characteristics in TLR8-transfected HEK293 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Inflammation-related Diseases

Chemical Information

CAS No. 1449680-12-9
Molecular Weight 254.33
Formula C₁₆H₁₈N₂O
SMILES

CCCCCC1=CC(C2=CC=CC=C2N=C3N)=C3O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kokatla HP, et al. Exquisite selectivity for human toll-like receptor 8 in substituted furo[2,3-c]quinolines. J Med Chem. 2013 Sep 12;56(17):6871-85.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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TLR8 agonist 11

All Toll-like Receptor (TLR) Isoforms

All NF-κB Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

TLR8 agonist 11 Related Classifications

HY-188010 Related Classifications

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