TNF-α-IN-19
Based on 1 Customer Validation
TNF-α-IN-19 is an inhibitor of TNFα that can block the interaction between TNFαRI, TRADD, and RIP1, the EC50 values for TNFα, IL-1β, and IL-1β/TNFα are 2.451, 3.792 and 1.54 μM, respectively. TNF-α-IN-19 only inhibits the degradation of IκBα when cells are stimulated by TNFα and not by IL-1β.
For research use only. We do not sell to patients.
- Purity : 99.9%
- CAS No.: 338773-13-0
- Formula: C16H8ClF3N4
- Molecular Weight:348.71
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
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IL-1β |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| 2008 | IC50 |
2.5 μM
Compound: 7, LQ011
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Cytotoxicity against human cDDP-sensitive 2008 cells after 72 hrs using crystal violet staining by spectrophotometric analysis
Cytotoxicity against human cDDP-sensitive 2008 cells after 72 hrs using crystal violet staining by spectrophotometric analysis
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[PMID: 20951595] |
| A2780 | IC50 |
2.3 μM
Compound: 7, LQ011
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Cytotoxicity against human cDDP-sensitive A2780 cells after 72 hrs using crystal violet staining by spectrophotometric analysis
Cytotoxicity against human cDDP-sensitive A2780 cells after 72 hrs using crystal violet staining by spectrophotometric analysis
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[PMID: 20951595] |
| A2780 | IC50 |
4.7 μM
Compound: 7, LQ011
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Cytotoxicity against human cDDP-resistant A2780 cells after 72 hrs using crystal violet staining by spectrophotometric analysis
Cytotoxicity against human cDDP-resistant A2780 cells after 72 hrs using crystal violet staining by spectrophotometric analysis
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[PMID: 20951595] |
| C13 | IC50 |
3.4 μM
Compound: 7, LQ011
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Cytotoxicity against human cDDP-resistant C13 cells after 72 hrs using crystal violet staining by spectrophotometric analysis
Cytotoxicity against human cDDP-resistant C13 cells after 72 hrs using crystal violet staining by spectrophotometric analysis
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[PMID: 20951595] |
| Vero | IC50 |
1.2 μM
Compound: 7, LQ011
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Cytotoxicity against african green monkey Vero cells after 72 hrs using crystal violet staining by spectrophotometric analysis
Cytotoxicity against african green monkey Vero cells after 72 hrs using crystal violet staining by spectrophotometric analysis
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[PMID: 20951595] |
Chemical Information
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CAS No. 338773-13-0
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Appearance Solid
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Molecular Weight 348.71
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Formula C16H8ClF3N4
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Color White to off-white
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SMILES
ClC1=CC=C(C2=NN=C3N2C4=C(N=C3C(F)(F)F)C=CC=C4)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TNF-α-IN-19 Related Classifications
HY-114573 Related Classifications
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