trans-Vaccenic acid-d13
trans-Vaccenic acid-d13 is deuterium labeled trans-Vaccenic acid (HY-113427). trans-Vaccenic acid is a naturally occurring trans fatty acid (TFA). trans-Vaccenic acid inhibits nasopharyngeal carcinoma (NPC) cell growth and induces apoptosis through the inhibition of Bad/Akt phosphorylation. trans-Vaccenic acid is a precursor for the synthesis of saturated fatty acid in the rumen and of conjugated Linoleic acid (CLA) at the tissue level. trans-Vaccenic acid exerts hypolipidemic effects in a rat model of obesity.
For research use only. We do not sell to patients.
- Formula: C18H21D13O2
- Molecular Weight:295.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
- Western Blot
- Annexin V plus membrane-impermeant dye apoptosis staining
- Somatic Cell Culture
- CCK-8/WST-8 Cell Proliferation Assay
- Cell Counting-Based Growth Curve Assay
- Research Protocol for Metabolic Diseases
- Cell Viability Determination by MTT Colorimetric Assay
- How to Choose the Right Model Animal
- Kinase activity and phosphorylation assays
- Detection of Apoptosis
- TUNEL staining for apoptotic DNA fragmentation
- Human pluripotent stem cell neural induction and neuron differentiation
- Protocol for Cell Counting and Cell Density Analysis
- How to Select a Suitable Non-Mouse Animal Model
- Apoptosis Solutions
- Protocol for Kinase activity and phosphorylation assays
- MTT Cell Proliferation Assay
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled CAS 693-72-1
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Molecular Weight 295.54
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Formula C18H21D13O2
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SMILES
OC(CCCCCCCCC/C=C/C([2H])(C([2H])(C([2H])(C([2H])(C(C([2H])([2H])[2H])([2H])[2H])[2H])[2H])[2H])[2H])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Li D, et al. Ruminal microbe of biohydrogenation of trans-vaccenic acid to stearic acid in vitro. BMC Res Notes. 2012 Feb 15;5:97. [Content Brief]
[3]. Song J, et al. Trans-vaccenic acid inhibits proliferation and induces apoptosis of human nasopharyngeal carcinoma cells via a mitochondrial-mediated apoptosis pathway. Lipids Health Dis. 2019 Feb 9;18(1):46. [Content Brief]
[4]. Jacome-Sosa MM, et al. Diets enriched in trans-11 vaccenic acid alleviate ectopic lipid accumulation in a rat model of NAFLD and metabolic syndrome. J Nutr Biochem. 2014 Jul;25(7):692-701. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
trans-Vaccenic acid-d13 Related Classifications
HY-113427S Related Classifications
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