Based on 1 Customer Validation
TTNPB (Ro 13-7410) (GMP) is TTNPB (HY-15682) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. TTNPB is a highly potent retinoic acid receptor (RAR) agonist.
For research use only. We do not sell to patients.
- CAS No.: 71441-28-6
- Formula: C24H28O2
- Molecular Weight:348.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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HY-15682
TTNPBApoptosis Inducer -
HY-14652
TamibaroteneApoptosis Inducer -
HY-14649
Retinoic acidRAR Agonist -
HY-15388
TazaroteneRAR Agonist -
HY-14649R
Retinoic acid (Standard) -
HY-14649G
Retinoic acid (GMP)RAR Agonist -
HY-14171
BexaroteneRXR Agonist -
HY-15682R
TTNPB (Standard)Apoptosis Inducer -
HY-B0091
AdapaleneRAR Agonist -
HY-15127
IsotretinoinAnti-acne Agent -
HY-10475
AM580RARα Agonist -
HY-14799
PalovaroteneRARγ Agonist
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CV-1 | EC50 |
>10000 nM
Compound: TTNPB
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Binding affinity against retinoic Acid X beta receptors co-transfected into CV-1 cells
Binding affinity against retinoic Acid X beta receptors co-transfected into CV-1 cells
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[PMID: 8308867] |
| CV-1 | EC50 |
>10000 nM
Compound: TTNPB
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Binding affinity against retinoic Acid X gamma receptors co-transfected into CV-1 cells
Binding affinity against retinoic Acid X gamma receptors co-transfected into CV-1 cells
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[PMID: 8308867] |
| CV-1 | EC50 |
2 nM
Compound: TTNPB
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Binding affinity against retinoic Acid gamma receptors co-transfected into CV-1 cells
Binding affinity against retinoic Acid gamma receptors co-transfected into CV-1 cells
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[PMID: 8308867] |
| CV-1 | EC50 |
3 nM
Compound: TTNPB
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Binding affinity against retinoic Acid beta receptors co-transfected into CV-1 cells
Binding affinity against retinoic Acid beta receptors co-transfected into CV-1 cells
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[PMID: 8308867] |
| CV-1 | EC50 |
30 nM
Compound: TTNPB
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Binding affinity against retinoic Acid alpha receptors co-transfected into CV-1 cells
Binding affinity against retinoic Acid alpha receptors co-transfected into CV-1 cells
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[PMID: 8308867] |
| CV-1 | EC50 |
>10000 nM
Compound: TTNPB
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Binding affinity against retinoic Acid X alpha receptors co-transfected into CV-1 cells
Binding affinity against retinoic Acid X alpha receptors co-transfected into CV-1 cells
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[PMID: 8308867] |
| F9 | ED50 |
0.08 nM
Compound: 2
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Ability to displace 3 uM retinoid and [3H]all-trans-retinoic acid in F9 embryonal carcinoma cells using F9 Plasminogen Activator releasing assay
Ability to displace 3 uM retinoid and [3H]all-trans-retinoic acid in F9 embryonal carcinoma cells using F9 Plasminogen Activator releasing assay
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[PMID: 2738885] |
| F9 | ED50 |
1.5 nM
Compound: 2
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Ability to displace [3H]all-trans-retinoic acid from F9 embryonal carcinoma cells, was assessed in a F9 laminin release assay
Ability to displace [3H]all-trans-retinoic acid from F9 embryonal carcinoma cells, was assessed in a F9 laminin release assay
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[PMID: 2738885] |
| HEK293 | EC50 |
0.18 nM
Compound: TTNPB
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Agonist activity at human RARalpha expressed in HEK293 cells by luciferase reporter gene assay
Agonist activity at human RARalpha expressed in HEK293 cells by luciferase reporter gene assay
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[PMID: 25305688] |
| HL-60 | IC50 |
46 μM
Compound: 3
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In vitro cytotoxicity against HL60 cells.
In vitro cytotoxicity against HL60 cells.
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[PMID: 11128648] |
| HL-60 | ED50 |
2.4 x 10-9 M
Compound: TTNPB (3)
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The ability to induce differentiation of human promyelocytic leukemia HL-60 cell line to mature granulocyte
The ability to induce differentiation of human promyelocytic leukemia HL-60 cell line to mature granulocyte
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[PMID: 2709376] |
| HL-60 | EC50 |
>1000 nM
Compound: 1
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Transglutaminase activity in HL-60 cdm-1 cells
Transglutaminase activity in HL-60 cdm-1 cells
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[PMID: 7636843] |
| HL-60 | EC50 |
>1000 nM
Compound: 9 (TTNPB)
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Induction of transglutaminase (TGase) activity in HL-60 cells
Induction of transglutaminase (TGase) activity in HL-60 cells
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[PMID: 8784454] |
In Vitro
The combination of TTNPB (Ro 13-7410) (GMP) (100 nM) and Laduviglusib (HY-10182) can induce chondrogenic markers in hiPSCs[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 71441-28-6
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Appearance Solid
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Molecular Weight 348.48
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Formula C24H28O2
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Color White to off-white
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SMILES
O=C(O)C1=CC=C(/C=C(C2=CC=C3C(C)(C)CCC(C)(C)C3=C2)\C)C=C1
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Synonyms
Ro 13-7410 (GMP); Arotinoid acid (GMP); AGN191183 (GMP)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Pignatello MA, et al. Multiple factors contribute to the toxicity of the aromatic retinoid, TTNPB (Ro 13-7410): binding affinities and disposition. Toxicol Appl Pharmacol. 1997 Feb;142(2):319-27. [Content Brief]
[2]. Manabu Kawata, et al. Simple and Robust Differentiation of Human Pluripotent Stem Cells toward Chondrocytes by Two Small-Molecule Compounds. Stem Cell Reports. 2019 Sep 10;13(3):530-544. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TTNPB (GMP) Related Classifications
HY-15682G Related Classifications
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