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Cat. No.: HY-186382

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Tyrosine kinase-IN-13

Tyrosine kinase-IN-13 is a Tyrosine kinase inhibitor with IC₅₀ values of 1~10 μM against ALK and ROS1. Tyrosine kinase-IN-13 exhibits anticancer activity against lung cancer.

For research use only. We do not sell to patients.

CAS No.: 2114400-64-3
Formula: C₃₁H₃₂ClF₃N₆O₂
Molecular Weight:613.07

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Tyrosine kinase-IN-13 Chemical Structure

CAS No.: 2114400-64-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Tyrosine kinase-IN-13 is a Tyrosine kinase inhibitor with IC₅₀ values of 1~10 μM against ALK and ROS1. Tyrosine kinase-IN-13 exhibits anticancer activity against lung cancer^[1].

In Vitro

Anti-cancerOthers

Anti-cancer

Tyrosine kinase-IN-13 (48 h) inhibits the growth of lung cancer cells H3122 and HCC-78, with IC₅₀ values of 0.1~10 μM^[1].

Others

Tyrosine kinase-IN-13 (Compound I-19) inhibits ALK and ROS1 with IC₅₀ values of 1~10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

H3122, HCC-78
Concentration:

Various concentrations
Incubation Time:

48 h
Result:

Inhibited the proliferation of both cell types, with IC₅₀ values in the range of 0.1-10 μM.

Chemical Information

CAS No. 2114400-64-3
Molecular Weight 613.07
Formula C₃₁H₃₂ClF₃N₆O₂
SMILES

O=C(C1=CC=CC(C(C)OC2=CC(NC3=CN(C4CCN(CC4)C)N=C3)=NC=C2)=C1)NCC5=CC=C(C(C(F)(F)F)=C5)Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhang, et al. 3 (1 (aminopyridine epoxide) ethyl) heterocyclic carbamate derivatives and its synthetic method and application. CN106866627A. China. 2017-01-24.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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