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Cat. No.: HY-P1696

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U 70714E

U 70714E is a Renin inhibitor with an IC₅₀ of 3.0 nM. U 70714E is used for the research of renin-related hypertension.

For research use only. We do not sell to patients.

CAS No.: 114376-16-8
Formula: C₆₆H₇₆N₁₂O₁₀
Molecular Weight:1197.38

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Custom Peptide Synthesis

U 70714E Chemical Structure

CAS No.: 114376-16-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

U 70714E is a Renin inhibitor with an IC₅₀ of 3.0 nM. U 70714E is used for the research of renin-related hypertension^[1].

In Vitro

Cardiovascular Regulation

U 70714E potently inhibits plasma renin in vitro, with an IC₅₀ of 3.0 nM, which is 2700 times more potent than the reference compound RIP^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Cardiovascular Diseases

Chemical Information

CAS No. 114376-16-8
Molecular Weight 1197.38
Formula C₆₆H₇₆N₁₂O₁₀
Sequence

Ac-Trp(formyl)-Pro-Phe-His-Phe(deoxy)-Phe-Val-Tyr-NH2
Sequence Shortening

Ac-Trp(formyl)-PFH-Phe(deoxy)-FVY-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Epps DE, et al. Structure-conformation relationships of synthetic peptide inhibitors of human renin studied by resonance energy transfer and molecular modeling. International journal of peptide and protein research. 1988 Jan;31(1):22-34.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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