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Cat. No.: HY-145934B

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UDP-GlcNAz

Name: UDP-GlcNAz
Brand: MedChemExpress
SKU: HY-145934B
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1 Cited Publications

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Based on 1 publication(s) in Google Scholar

UDP-GlcNAz is a UDP sugar. UDP-GlcNAz transfers GlcNAz to serine and threonine residues during O-GlcNAcylation and causes GlcNAz modification of substrate proteins (including recombinant mouse iNOS), which can be detected via Staudinger ligation with biotin-phosphine. UDP-GlcNAz provides a click chemistry handle through its azide group for the enrichment and fluorescence detection of O-GlcNAcylated proteins.

For research use only. We do not sell to patients.

CAS No.: 608514-41-6
Formula: C₁₇H₂₆N₆O₁₇P₂
Molecular Weight:648.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

UDP-GlcNAz Chemical Structure

CAS No.: 608514-41-6

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Publications (1)
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Bioz

Biological Activity

Description

In Vitro

Carbohydrate Metabolism

UDP-GlcNAz supports direct O-GlcNAcylation of recombinant mouse iNOS by OGT in an in vitro OGT assay^[1].
UDP-GlcNAz (40 μM) is utilized by recombinant ncOGT as a substrate in the UDP-Glo assay, with UDP-4FGalNAz being accepted less efficiently than UDP-GlcNAz^[2].
UDP-GlcNAz enables click-chemistry fluorescent detection with reduced background and identifies an asparagine ladder in the OGT TPR domain important for protein substrate binding in a cell-free protein microarray of ∼8,000 human proteins with purified OGT^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

EdU Incorporation Assay (Click Chemistry-Based DNA Synthesis Measurement)

Chemical Information

CAS No. 608514-41-6
Molecular Weight 648.37
Formula C₁₇H₂₆N₆O₁₇P₂
SMILES

O=C(C=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(OP(O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3NC(CN=[N+]=[N-])=O)(O)=O)(O)=O)O2)NC1=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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bioRxiv

2026 Jun 29.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Abramowitz LK, et al. Chronically Elevated -GlcNAcylation Limits Nitric Oxide Production and Deregulates Specific Pro-Inflammatory Cytokines. Frontiers in immunology. 2022;13:802336.

[2]. Jackson EG, et al. 4-Deoxy-4-fluoro-GalNAz (4FGalNAz) Is a Metabolic Chemical Reporter of O-GlcNAc Modifications, Highlighting the Notable Substrate Flexibility of O-GlcNAc Transferase. ACS chemical biology. 2022 Jan 21;17(1):159-170.

[3]. Estevez A, et al. Molecular Interrogation to Crack the Case of O-GlcNAc. Chemistry (Weinheim an der Bergstrasse, Germany). 2020 Sep 21;26(53):12086-12100.

[4]. Mayer A, et al. 6''-Azido-6''-deoxy-UDP-N-acetylglucosamine as a glycosyltransferase substrate. Bioorganic & medicinal chemistry letters. 2011 Feb 15;21(4):1199-201.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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Biological Activity
- Description
- In Vitro
Chemical Information
Publications (1)
Purity & Documentation
References

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UDP-GlcNAz

Publications Citing Use of MedChemExpress (MCE) UDP-GlcNAz