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Cat. No.: HY-111281

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UK 39671

UK 39671 is a store-operated calcium permeability inhibitor with an IC₅₀ of 10 μM in thymocytes. UK 39671 prevents the acceleration of Mn²⁺ influx in thymocytes with intracellular calcium store depletion.

For research use only. We do not sell to patients.

CAS No.: 85473-17-2
Formula: C₁₇H₂₂Cl₂N₂O
Molecular Weight:341.28

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Please store the product under the recommended conditions in the Certificate of Analysis.

UK 39671 Chemical Structure

CAS No.: 85473-17-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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Biological Activity

Description

In Vitro

UK 39671 (10 μM) potently inhibits store-regulated plasma membrane Ca²⁺/Mn²⁺ permeability in rat thymocytes with an IC₅₀ of 10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Chemical Information

CAS No. 85473-17-2
Molecular Weight 341.28
Formula C₁₇H₂₂Cl₂N₂O
SMILES

ClC1=CC=C(C(Cl)=C1)C(O)(CN2C=NC=C2)CCCCCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Alvarez J, et al. Cytochrome P450 may regulate plasma membrane Ca2+ permeability according to the filling state of the intracellular Ca2+ stores. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1992 Jan 06;6(2):786-92. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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