UNC5452
UNC5452 is a selective, ATP-competitive Nek1 kinase inhibitor with an IC50 of 7.1 μM. UNC5452 inhibits IKKβ kinase activity. UNC5452 can be used for research on polycystic kidney disease.
For research use only. We do not sell to patients.
- CAS No.: 943434-15-9
- Formula: C17H20N4O2S
- Molecular Weight:344.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
IKKβ |
NEK1 7.1 μM (IC50) |
In Vitro
UNC5452 inhibits recombinant Nek1 in a TR-FRET-based activity assay with an IC50 of 7.1 μM[1].
UNC5452 (1 μM) is a potent and selective Nek1 inhibitor (99.8% inhibition at 1 μM) with a narrow kinome profile, indicating that the 4-aryl-7-azaindole scaffold is a promising chemical starting point for Nek1-directed development[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 943434-15-9
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Molecular Weight 344.43
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Formula C17H20N4O2S
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SMILES
O=S(=O)(NCCN(C)C)C=1C=CC(=CC1)C=2C=CN=C3NC=CC32
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
UNC5452 Related Classifications
HY-189144 Related Classifications
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