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Cat. No.: HY-N21685

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Uralione D

Uralione D is a neuroprotective agent found in Hypericum uralum and Hypericum kouytchense. Uralione D exhibits cytotoxic activity against gastric cancer cells and protects against Corticosterone (HY-B1618)-induced damage in neuron-like cells. Uralione D is useful for research on depression, multidrug-resistant liver cancer, and gastric cancer.

For research use only. We do not sell to patients.

CAS No.: 1927024-52-9
Formula: C₃₈H₅₂O₇
Molecular Weight:620.82

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Uralione D Chemical Structure

CAS No.: 1927024-52-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

All Endogenous Metabolite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MKN-45	IC50	18.47 μM	Cytotoxicity against human MKN-45 gastric cancer cells assessed as reduction in cell viability incubated for 24 h by Cell Counting Kit-8 (CCK-8) assay. Cytotoxicity against human MKN-45 gastric cancer cells assessed as reduction in cell viability incubated for 24 h by Cell Counting Kit-8 (CCK-8) assay.	slct.202504003

In Vitro

Anti-cancerOthers

Anti-cancer

Uralione D (compound 5) (24 h) exerts potent cytotoxicity against human MKN-45 gastric cancer cells, with an IC₅₀ value of 18.47 µM after 24 h of treatment^[3].

Others

Uralione D (compound 4) (0.1-10.0 μM; 48 h) protects PC12 cells from Corticosterone (HY-B1618)-induced injury, with cell viabilities ranging from 72.5% to 80.9% across 0.1-10.0 μM concentrations after 48 h of co-incubation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

PC12 cells
Concentration:

0.1, 0.3, 1.0, 3.0, 10.0 μM
Incubation Time:

48 h
Result:

Exhibited significant protective effects against corticosterone-induced PC12 cell injury at all tested concentrations.
Showed cell viability of 77.9% at 0.1 μM relative to untreated control set at 100%.
Showed cell viability of 77.7% at 0.3 μM relative to untreated control set at 100%.
Showed cell viability of 78.5% at 1.0 μM relative to untreated control set at 100%.
Showed cell viability of 72.5% at 3.0 μM relative to untreated control set at 100%.
Showed cell viability of 80.9% at 10.0 μM relative to untreated control set at 100%.
Achieved the highest viability at 10.0 μM.

Related Protocols :

Chemical Information

CAS No. 1927024-52-9
Molecular Weight 620.82
Formula C₃₈H₅₂O₇
SMILES

O=C(C1=CC=CC=C1)[C@]23C4=C(C[C@@H](C(C)(O4)C)O)C([C@](C2=O)(C[C@@H]([C@@]3(C)CC/C=C(C)/C)C/C=C(C)\C)C[C@H](O)C(C)(O)C)=O
Structure Classification
- Terpenoids
- Other Monoterpenes
- Ketones, Aldehydes, Acids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhou ZB, et al. Polycyclic Polyprenylated Derivatives from Hypericum uralum: Neuroprotective Effects and Antidepressant-like Activity of Uralodin A. Journal of natural products. 2016 May 27;79(5):1231-40.

[2]. Lou HY, et al. Hyperkouytones A-O, new polyprenylated acylphloroglucinols from Hypericum kouytchense with multidrug resistance reversal activity. Chin J Chem. 2024;42(24):3293-3307.

[3]. Jing C, et al. Polycyclic polyprenylated acylphloroglucinols (PPAPs) kouytchin A‑B and a tetramethoxydibenzo[1,4]dioxin from Hypericum kouytchense: isolation and cytotoxic evaluation. ChemistrySelect. 2026;11(1):e04003.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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