USP7-IN-2
USP7-IN-2 (compound 4) is a non-competitive USP7 inhibitor with an IC50 of 6 nM. USP7-IN-2 causes degradation of MDM2, stabilization of p53 and induction of p21 in multiple cell lines, and can be utilized in cancer research.
For research use only. We do not sell to patients.
- CAS No.: 2196243-57-7
- Formula: C29H34N6O3
- Molecular Weight:514.62
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| JeKo-1 | IC50 |
>20000 nM
Compound: 27
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Antiproliferative activity against human JeKo-1 cells harbouring p53 mutant
Antiproliferative activity against human JeKo-1 cells harbouring p53 mutant
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[PMID: 36306471] |
| MM1.S | IC50 |
585.6 nM
Compound: ALM4
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Antiproliferative activity against human MM1.S cells assessed as inhibition of cell proliferation incubated for 3 days by SRB assay
Antiproliferative activity against human MM1.S cells assessed as inhibition of cell proliferation incubated for 3 days by SRB assay
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[PMID: 39133975] |
| REH | IC50 |
20.3 nM
Compound: 4
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Antiproliferative activity against human REH cells with wild type p53 assessed as cell viability measured after 3 days by PMS-MTS assay
Antiproliferative activity against human REH cells with wild type p53 assessed as cell viability measured after 3 days by PMS-MTS assay
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[PMID: 39028938] |
| RS4-11 | IC50 |
>20000 nM
Compound: 4
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Antiproliferative activity against human RS4-11 cells with shp53 assessed as cell viability measured after 7 days by PMS-MTS assay
Antiproliferative activity against human RS4-11 cells with shp53 assessed as cell viability measured after 7 days by PMS-MTS assay
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[PMID: 39028938] |
| RS4-11 | IC50 |
69 nM
Compound: 4
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Antiproliferative activity against human RS4-11 cells with wild type p53 assessed as cell viability measured after 3 days by PMS-MTS assay
Antiproliferative activity against human RS4-11 cells with wild type p53 assessed as cell viability measured after 3 days by PMS-MTS assay
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[PMID: 39028938] |
Chemical Information
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CAS No. 2196243-57-7
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Appearance Solid
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Molecular Weight 514.62
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Formula C29H34N6O3
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Color White to off-white
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SMILES
O=C1C2=NN(C)C(C3=CC=C(CN)C=C3)=C2N=CN1CC4(O)CCN(C(C[C@H](C5=CC=CC=C5)C)=O)CC4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (194.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9432 mL | 9.7159 mL | 19.4318 mL | 48.5795 mL |
| 5 mM | 0.3886 mL | 1.9432 mL | 3.8864 mL | 9.7159 mL | |
| 10 mM | 0.1943 mL | 0.9716 mL | 1.9432 mL | 4.8580 mL | |
| 15 mM | 0.1295 mL | 0.6477 mL | 1.2955 mL | 3.2386 mL | |
| 20 mM | 0.0972 mL | 0.4858 mL | 0.9716 mL | 2.4290 mL | |
| 25 mM | 0.0777 mL | 0.3886 mL | 0.7773 mL | 1.9432 mL | |
| 30 mM | 0.0648 mL | 0.3239 mL | 0.6477 mL | 1.6193 mL | |
| 40 mM | 0.0486 mL | 0.2429 mL | 0.4858 mL | 1.2145 mL | |
| 50 mM | 0.0389 mL | 0.1943 mL | 0.3886 mL | 0.9716 mL | |
| 60 mM | 0.0324 mL | 0.1619 mL | 0.3239 mL | 0.8097 mL | |
| 80 mM | 0.0243 mL | 0.1214 mL | 0.2429 mL | 0.6072 mL | |
| 100 mM | 0.0194 mL | 0.0972 mL | 0.1943 mL | 0.4858 mL |
USP7-IN-2 Related Classifications
HY-122646 Related Classifications
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