VEGFR-2-IN-92
VEGFR-2-IN-92 is a potent VEGFR-2 inhibitor (IC50 = 0.208 μM). VEGFR-2-IN-92 occupies the inactive conformation of VEGFR-2 to inhibit its kinase activity, thereby disrupting the Cyclin D1-CDK4/6-Rb signaling axis and the p-FAK-related survival pathway, ultimately leading to cell cycle arrest and apoptosis in cancer cells. VEGFR-2-IN-92 can be used for research on colorectal cancer.
For research use only. We do not sell to patients.
- Formula: C26H22N4O5
- Molecular Weight:470.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All VEGFR Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
VEGFR2 0.208 μM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
2.97 μM
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Antiproliferative activity against human HCT-116 colorectal carcinoma cells assessed as reduction in cell viability by MTT assay.
Antiproliferative activity against human HCT-116 colorectal carcinoma cells assessed as reduction in cell viability by MTT assay.
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42561564 |
| HepG2 | IC50 |
53.4 μM
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Antiproliferative activity against human HepG2 hepatocellular carcinoma cells assessed as reduction in cell viability by MTT assay.
Antiproliferative activity against human HepG2 hepatocellular carcinoma cells assessed as reduction in cell viability by MTT assay.
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42561564 |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
- Kinase activity and phosphorylation assays
- Detection of Apoptosis
- TUNEL staining for apoptotic DNA fragmentation
- Flow cytometric DNA-content cell-cycle staining
- Annexin V plus membrane-impermeant dye apoptosis staining
- BrdU Incorporation Assay
- Apoptosis Solutions
- Protocol for Cell Cycle
- Protocol for Kinase activity and phosphorylation assays
Chemical Information
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Molecular Weight 470.48
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Formula C26H22N4O5
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SMILES
O=C(C1=CC=C(C=C1)NC(CN2C(C3(C4=CC=CC=C42)OCCO3)=O)=O)N/N=C/C5=CC=CC=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
VEGFR-2-IN-92 Related Classifications
HY-189404 Related Classifications
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