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Cat. No.: HY-189917

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VHL Ligand 45

VHL Ligand 45 is a VHL ligand. VHL Ligand 45 is applicable to research related to PROTAC synthesis, such as serving as the E3 protease ligand of PROTAC EGFR degrader 20 (HY-189915).

For research use only. We do not sell to patients.

CAS No.: 3011029-52-7
Formula: C₂₆H₃₃FN₄O₄S₂
Molecular Weight:548.69

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

VHL Ligand 45 Chemical Structure

CAS No.: 3011029-52-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
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Biological Activity

Description

VHL Ligand 45 is a VHL ligand. VHL Ligand 45 is applicable to research related to PROTAC synthesis, such as serving as the E3 protease ligand of PROTAC EGFR degrader 20 (HY-189915)^[1].

IC₅₀ & Target

^[1]

VHL

All Ligands for E3 Ligase Isoforms :

In Vitro

Protein/Amino Acid Metabolism

VHL Ligand 45 can serve as the E3 ligase ligand for PROTAC EGFR degrader 20 (HY-189915), an orally active and blood-brain barrier-penetrant EGFR PROTAC degrader that selectively degrades mutant EGFR, with DC₅₀ = 9.14 nM in HCC827 cells (EGFR^Del19) and DC₅₀ = 15.2 nM in H3255 cells (EGFR^L858R)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3011029-52-7
Molecular Weight 548.69
Formula C₂₆H₃₃FN₄O₄S₂
SMILES

O=C(C1(CC1)F)N[C@@H](C(C)(S)C)C(N2[C@@H](C[C@H](C2)O)C(N[C@H](C3=CC=C(C4=C(C)N=CS4)C=C3)C)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ni X, et al. Discovery of Potent and Selective VHL‑Recruiting PROTAC Degraders Targeting EGFR with Improved Developability and Potent Anti‑NSCLC Efficacy. Journal of Medicinal Chemistry. 2026;69(19):22671‑22698.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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VHL Ligand 45

All Ligands for E3 Ligase Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

VHL Ligand 45 Related Classifications

HY-189917 Related Classifications

Bioz

Keywords

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