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Cat. No.: HY-P11922

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VMPWDEWLTKRKPELP

VMPWDEWLTKRKPELP is a chikungunya virus (CHIKV) nsP2 protease inhibitor with a IC₅₀ of 4.6 μM and a K_d of 1.39 μM. VMPWDEWLTKRKPELP can be used for the research of chikungunya fever.

For research use only. We do not sell to patients.

Formula: C₉₅H₁₄₅N₂₃O₂₄S
Molecular Weight:2025.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Custom Peptide Synthesis

VMPWDEWLTKRKPELP Chemical Structure

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Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

VMPWDEWLTKRKPELP (P1) (0-100 μM; overnight, 4 h, overnight) shows low cytotoxicity to cultured cells at concentrations up to 100 μM, providing a safe margin relative to its IC₅₀ of 4.6 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

unspecified cultured cells
Concentration:

0-100 μM
Incubation Time:

overnight (peptide treatment); 4 h (MTT incubation); overnight (solubilization incubation)
Result:

Exhibited low cytotoxicity, with no significant toxicity observed at concentrations up to 100 μM, which is approximately 20 times higher than its IC₅₀ value.

Chemical Information

Molecular Weight 2025.37
Formula C₉₅H₁₄₅N₂₃O₂₄S
Sequence

Val-Met-Pro-Trp-Asp-Glu-Trp-Leu-Thr-Lys-Arg-Lys-Pro-Glu-Leu-Pro
Sequence Shortening

VMPWDEWLTKRKPELP
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Mastalipour M. Dual Modulation of Chikungunya Virus nsP2 Protease: Peptide-Mediated Inhibition and Nucleic Acid-Induced Activation[D]. Universitäts-und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2025.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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