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Cat. No.: HY-188197

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VtCD-cTP-ALKF-2

VtCD-cTP-ALKF-2 is a DAPK1 PROTAC degrader. VtCD-cTP-ALKF-2 can bind to dephosphorylated DAPK1, recruit VHL E3 ligase, and induce ubiquitin-proteasome-mediated degradation. VtCD-cTP-ALKF-2 can be used for research on Alzheimer's disease.
(Pink: DAPK1 ligand (HY-P12376); Blue: VHL ligand (HY-125845); Black: linker (HY-22408)).

For research use only. We do not sell to patients.

Formula: C₂₁₀H₃₁₄F₁₂N₆₀O₅₀S₃
Molecular Weight:4803.29

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

VtCD-cTP-ALKF-2 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

VtCD-cTP-ALKF-2 is a DAPK1 PROTAC degrader. VtCD-cTP-ALKF-2 can bind to dephosphorylated DAPK1, recruit VHL E3 ligase, and induce ubiquitin-proteasome-mediated degradation. VtCD-cTP-ALKF-2 can be used for research on Alzheimer's disease^[1]. (Pink: DAPK1 ligand (HY-P12376); Blue: VHL ligand (HY-125845); Black: linker (HY-22408)).

All PROTACs Isoforms :

In Vitro

Oxidative StressAβ/Tau/α-Synuclein AggregationProtein/Amino Acid MetabolismOthers

Oxidative Stress

Aβ/Tau/α-Synuclein Aggregation

Protein/Amino Acid Metabolism

VtCD-cTP-ALKF-2 (10 μM; 12-48 h washout monitoring), generated from its caged precursor, induces ROS- and proteasome-dependent DAPK1 degradation with 62% reduction of total DAPK1 and downstream reduction of p-APP and p-Tau in Aβ42 oligomer-induced SH-SY5Y cells^[1].

Others

VtCD-cTP-ALKF-2 (100 μM H₂O₂; 24 h) is generated from its caged precursor with near-complete conversion and remains stable at pH 7.4 without H₂O₂^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Alzheimer’s Disease Modeling

Chemical Information

Molecular Weight 4803.29
Formula C₂₁₀H₃₁₄F₁₂N₆₀O₅₀S₃
SMILES

OC1=CC=C(C[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCCN)NC([C@@H](CC2)CC[C@@H]2C(N[C@H](C(N3[C@@H](C[C@H](C3)O)C(NCC4=CC=C(C5=C(C)N=CS5)C=C4)=O)=O)C(C)(C)C)=O)=O)=O)CCCCN)=O)CC(N)=O)=O)CCCNC(N)=N)=O)CC(N)=O)=O)CCCCN)=O)CC(C)C)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CC6=CNC=N6)=O)CO)=O)C(NCCCCCC(N[C@H]7CSC(C8=O)CC(N8CCC(OCC(F)(C(F)(C(F)(C(F)(C(F)(C(F)(COC(CCN9C(CC(C9=O)SC[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC7=O)CC%10=CNC=N%10)=O)CC(C)C)=O)CC(N)=O)=O)[C@H](CC)C)=O)CC(C)C)=O)CO)=O)[C@@H](C)O)=O)CC(C)C)=O)CC%11=CNC%12=CC=CC=C%12%11)=O)CCCCN)=O)CC%13=CC=C(O)C=C%13)=O)CCCNC(N)=N)=O)C(N)=O)=O)=O)F)F)F)F)F)F)=O)=O)=O)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Peng L, et al. Blood‑Brain Barrier‑Permeable Macrocyclic Chimeras (BmTACs) for Targeted Protein Degradation in the Aging Brain. J Am Chem Soc.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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