country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-163824

Copy Link Print Information

WIZ degrader 7

WIZ degrader 7 (Example 16) is a WIZ molecular glue degrader with an IC₅₀ value of < 0.01 μM. WIZ degrader 7 can be used to investigate sickle cell disease (SCD) and thalassemia.

For research use only. We do not sell to patients.

CAS No.: 3036553-83-7
Formula: C₂₉H₂₄N₆O₄
Molecular Weight:520.54

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (284 KB)

WIZ degrader 7 Chemical Structure

CAS No.: 3036553-83-7

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

WIZ degrader 7 (Example 16) is a WIZ molecular glue degrader with an IC₅₀ value of < 0.01 μM. WIZ degrader 7 can be used to investigate sickle cell disease (SCD) and thalassemia^[1].

All Histone Acetyltransferase Isoforms :

In Vitro

Sickle cell disease (SCD) is a group of serious inherited blood disorders that cause red blood cells to twist and deform into a sickle shape. These cells can cause blood flow obstruction, leading to severe pain, organ damage, and premature death. β-thalassemia is a group of inherited blood disorders caused by reduced or absent synthesis of β-globin, resulting in anemia. WIZ is widely expressed and plays a role in targeting G9a/GLP histone methyltransferases to genomic sites to regulate chromatin structure and transcription.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3036553-83-7
Molecular Weight 520.54
Formula C₂₉H₂₄N₆O₄
SMILES

O=C1C2=C(C(N1C3C(NC(CC3)=O)=O)=O)C(NC4=CC5=C(C=C4C6=CC(C)=NC=C6)N=CN5C7CC7)=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (284 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Thomas J, et al. Compounds and their use for treatment of hemoglobinopathies. WO2024097932A1.2024-05-10.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote