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Cat. No.: HY-D3639

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WX-02-33

WX-02-33 is a TOE1 inhibitor that covalently binds TOE1 and allosterically inhibits its 3′ RNA exonuclease activity. WX-02-33 promotes the binding of TOE1 to spliceosome-associated protein complexes involved in pre-mRNA splicing in a site-specific and stereoselective manner. WX-02-33 exhibits good proteome selectivity in cancer cells, binding only TOE1_C80 and a few other cysteines. WX-02-33 can be used for research on Merkel cell carcinoma.

For research use only. We do not sell to patients.

CAS No.: 3020765-74-3
Formula: C₂₆H₂₅N₃O₅
Molecular Weight:459.49

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

WX-02-33 Chemical Structure

CAS No.: 3020765-74-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

All DNA/RNA Synthesis Isoforms :

In Vitro

WX-02-33 (20 μM; 3 h) binds TOE1_C80 with over 80% occupancy in Ramos cells and acts selectively on cysteine across the whole proteome^[1].
WX-02-33 (20 μM; 6 h) inhibits deadenylation of WT-TOE1 but not the C80S-TOE1 mutant in immunoprecipitates derived from MCC142^[1].
WX-02-33 (20 μM; 6 h) promotes the binding of TOE1 to spliceosome-related complexes in MCC142 cells^[1].
WX-02-33 confers a greater advantage on C80S-TOE1 than on WT-TOE1 in the mixed MCC142 competition assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

RNA extraction experimental

Chemical Information

CAS No. 3020765-74-3
Molecular Weight 459.49
Formula C₂₆H₂₅N₃O₅
SMILES

C=CC(N1[C@H](C2=CC=C(OCO3)C3=C2)C4=C(C[C@@H]1C(N5CCOCC5)=O)C6=CC=CC=C6N4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Li H, et al. Assigning functionality to cysteines by base editing of cancer dependency genes. Nature chemical biology. 2023 Nov;19(11):1320-1330.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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